UniProt Accession

 PRS7_MOUSE; P46471; O08531; Q3TGX5; Q9DBA1 

Genbank Protein ID

 AK005083; AK168548; BC005462; U61283 

Genbank Nucleotide ID

 BAB23807.1; BAE40423.1; AAH05462.1; AAB51069.1 

Protein Name

 26S protease regulatory subunit 7 

Protein Synonyms/Alias

 26S proteasome AAA-ATPase subunit RPT1; Proteasome 26S subunit ATPase 2; Protein MSS1 

Gene Name

 Psmc2 

Gene Synonyms/Alias

 Mss1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
13	GADQRKTKEEEKDDK	ubiquitination	[1]
17	RKTKEEEKDDKPIRA	ubiquitination	[1]
34	EGDIALLKTYGQSTY	acetylation	[2]
34	EGDIALLKTYGQSTY	ubiquitination	[1]
46	STYSRQIKQVEDDIQ	ubiquitination	[1]
57	DDIQQLLKKINELTG	ubiquitination	[1]
58	DIQQLLKKINELTGI	ubiquitination	[1]
66	INELTGIKESDTGLA	ubiquitination	[1]
84	LWDLAADKQTLQSEQ	ubiquitination	[1]
100	LQVARCTKIINADSE	ubiquitination	[1]
110	NADSEDPKYIINVKQ	acetylation	[3]
110	NADSEDPKYIINVKQ	ubiquitination	[1]
116	PKYIINVKQFAKFVV	acetylation	[3]
116	PKYIINVKQFAKFVV	ubiquitination	[1]
120	INVKQFAKFVVDLSD	ubiquitination	[1]
146	RVGVDRNKYQIHIPL	ubiquitination	[1]
181	YSDVGGCKEQIEKLR	ubiquitination	[1]
186	GCKEQIEKLREVVET	ubiquitination	[1]
210	NLGIEPPKGVLLFGP	ubiquitination	[1]
222	FGPPGTGKTLCARAV	acetylation	[3]
222	FGPPGTGKTLCARAV	ubiquitination	[1]
248	IGSELVQKYVGEGAR	acetylation	[3]
248	IGSELVQKYVGEGAR	ubiquitination	[1]
316	FDPRGNIKVLMATNR	ubiquitination	[1]
340	RPGRLDRKIEFSLPD	ubiquitination	[1]
356	EGRTHIFKIHARSMS	ubiquitination	[1]
407	RRKIATEKDFLEAVN	acetylation	[3, 4]
407	RRKIATEKDFLEAVN	ubiquitination	[1]
415	DFLEAVNKVIKSYAK	acetylation	[3]
415	DFLEAVNKVIKSYAK	ubiquitination	[1]
422	KVIKSYAKFSATPRY	acetylation	[3]
422	KVIKSYAKFSATPRY	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 The 26S protease is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex. 

Sequence Annotation

 NP_BIND 216 223 ATP (Potential).
 MOD_RES 116 116 N6-acetyllysine (By similarity).
 MOD_RES 422 422 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Nucleus; Proteasome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 433 AA 

Protein Sequence

Gene Ontology

 GO:0000932; C:cytoplasmic mRNA processing body; IDA:UniProtKB.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0022624; C:proteasome accessory complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Compara. 

Interpro

 IPR005937; 26S_Psome_P45.
 IPR003593; AAA+_ATPase.
 IPR003959; ATPase_AAA_core.
 IPR003960; ATPase_AAA_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00004; AAA 

SMART

 SM00382; AAA 

PROSITE

 PS00674; AAA 

PRINTS