| Tag | Content |
|---|
| CPLM ID | CPLM-004000 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Neurofilament heavy polypeptide |
Protein Synonyms/Alias | NF-H; 200 kDa neurofilament protein; Neurofilament triplet H protein |
Gene Name | NEFH |
Gene Synonyms/Alias | KIAA0845; NFH |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 98 | VATSRSEKEQLQALN | ubiquitination | [1] | | 264 | AETRDALKCDVTSAL | ubiquitination | [1] |
|
Reference | [1] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR. J Biol Chem. 2011 Dec 2;286(48):41530-8. [ PMID: 21987572] |
Functional Description | Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins. |
Sequence Annotation | REPEAT 525 530 1.
REPEAT 531 536 2.
REPEAT 539 544 3.
REPEAT 545 550 4.
REPEAT 559 564 5.
REPEAT 573 578 6.
REPEAT 579 584 7.
REPEAT 593 598 8.
REPEAT 599 604 9.
REPEAT 613 618 10.
REPEAT 627 632 11.
REPEAT 633 638 12.
REPEAT 647 652 13.
REPEAT 653 658 14.
REPEAT 667 672 15.
REPEAT 673 678 16.
REPEAT 681 686 17.
REPEAT 687 692 18.
REPEAT 695 700 19.
REPEAT 701 706 20.
REPEAT 709 714 21.
REPEAT 715 720 22.
REPEAT 723 728 23.
REPEAT 729 734 24.
REPEAT 743 748 25.
REPEAT 751 756 26.
REPEAT 768 773 27.
REPEAT 792 797 28.
REPEAT 800 805 29.
REPEAT 827 832 30.
REGION 1 100 Head.
REGION 101 413 Rod.
REGION 101 132 Coil 1A.
REGION 133 145 Linker 1.
REGION 146 244 Coil 1B.
REGION 245 266 Linker 12.
REGION 267 288 Coil 2A.
REGION 289 292 Linker 2.
REGION 293 413 Coil 2B.
REGION 414 1026 Tail.
REGION 525 832 30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]-
MOD_RES 61 61 Phosphoserine (By similarity).
MOD_RES 503 503 Phosphoserine (By similarity).
MOD_RES 526 526 Phosphoserine (By similarity).
MOD_RES 532 532 Phosphoserine (By similarity).
MOD_RES 540 540 Phosphoserine (By similarity).
MOD_RES 546 546 Phosphoserine (By similarity).
MOD_RES 552 552 Phosphoserine (By similarity).
MOD_RES 560 560 Phosphoserine (By similarity).
MOD_RES 566 566 Phosphoserine (By similarity).
MOD_RES 574 574 Phosphoserine (By similarity).
MOD_RES 600 600 Phosphoserine (By similarity).
MOD_RES 606 606 Phosphoserine (By similarity).
MOD_RES 614 614 Phosphoserine (By similarity).
MOD_RES 620 620 Phosphoserine (By similarity).
MOD_RES 628 628 Phosphoserine (By similarity).
MOD_RES 634 634 Phosphoserine (By similarity).
MOD_RES 640 640 Phosphoserine (By similarity).
MOD_RES 648 648 Phosphoserine (By similarity).
MOD_RES 654 654 Phosphoserine (By similarity).
MOD_RES 660 660 Phosphoserine (By similarity).
MOD_RES 668 668 Phosphoserine (By similarity).
MOD_RES 674 674 Phosphoserine (By similarity).
MOD_RES 682 682 Phosphoserine (By similarity).
MOD_RES 688 688 Phosphoserine (By similarity).
MOD_RES 696 696 Phosphoserine (By similarity).
MOD_RES 702 702 Phosphoserine (By similarity).
MOD_RES 710 710 Phosphoserine (By similarity).
MOD_RES 724 724 Phosphoserine (By similarity).
MOD_RES 769 769 Phosphoserine (By similarity).
MOD_RES 774 774 Phosphothreonine (By similarity).
MOD_RES 801 801 Phosphoserine (By similarity).
MOD_RES 828 828 Phosphoserine (By similarity). |
Keyword | Alternative splicing; Amyotrophic lateral sclerosis; Coiled coil; Complete proteome; Disease mutation; Intermediate filament; Neurodegeneration; Phosphoprotein; Polymorphism; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1026 AA |
Protein Sequence | MMSFGGADAL LGAPFAPLHG GGSLHYALAR KGGAGGTRSA AGSSSGFHSW TRTSVSSVSA 60
SPSRFRGAGA ASSTDSLDTL SNGPEGCMVA VATSRSEKEQ LQALNDRFAG YIDKVRQLEA 120
HNRSLEGEAA ALRQQQAGRS AMGELYEREV REMRGAVLRL GAARGQLRLE QEHLLEDIAH 180
VRQRLDDEAR QREEAEAAAR ALARFAQEAE AARVDLQKKA QALQEECGYL RRHHQEEVGE 240
LLGQIQGSGA AQAQMQAETR DALKCDVTSA LREIRAQLEG HAVQSTLQSE EWFRVRLDRL 300
SEAAKVNTDA MRSAQEEITE YRRQLQARTT ELEALKSTKD SLERQRSELE DRHQADIASY 360
QEAIQQLDAE LRNTKWEMAA QLREYQDLLN VKMALDIEIA AYRKLLEGEE CRIGFGPIPF 420
SLPEGLPKIP SVSTHIKVKS EEKIKVVEKS EKETVIVEEQ TEETQVTEEV TEEEEKEAKE 480
EEGKEEEGGE EEEAEGGEEE TKSPPAEEAA SPEKEAKSPV KEEAKSPAEA KSPEKEEAKS 540
PAEVKSPEKA KSPAKEEAKS PPEAKSPEKE EAKSPAEVKS PEKAKSPAKE EAKSPAEAKS 600
PEKAKSPVKE EAKSPAEAKS PVKEEAKSPA EVKSPEKAKS PTKEEAKSPE KAKSPEKAKS 660
PEKEEAKSPE KAKSPVKAEA KSPEKAKSPV KAEAKSPEKA KSPVKEEAKS PEKAKSPVKE 720
EAKSPEKAKS PVKEEAKTPE KAKSPVKEEA KSPEKAKSPE KAKTLDVKSP EAKTPAKEEA 780
RSPADKFPEK AKSPVKEEVK SPEKAKSPLK EDAKAPEKEI PKKEEVKSPV KEEEKPQEVK 840
VKEPPKKAEE EKAPATPKTE EKKDSKKEEA PKKEAPKPKV EEKKEPAVEK PKESKVEAKK 900
EEAEDKKKVP TPEKEAPAKV EVKEDAKPKE KTEVAKKEPD DAKAKEPSKP AEKKEAAPEK 960
KDTKEEKAKK PEEKPKTEAK AKEDDKTLSK EPSKPKAEKA EKSSSTDQKD SKPPEKATED 1020
KAAKGK 1026 |
Gene Ontology | GO:0005739; C:mitochondrion; IEA:Compara. GO:0005883; C:neurofilament; NAS:UniProtKB. GO:0008219; P:cell death; IEA:UniProtKB-KW. GO:0045110; P:intermediate filament bundle assembly; IEA:Compara. GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara. GO:0007399; P:nervous system development; NAS:UniProtKB. GO:0060052; P:neurofilament cytoskeleton organization; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |