UniProt Accession

 E2F6_HUMAN; O75461; A8K2Z8; O60544; Q53QY9; Q7Z2H6 

Genbank Protein ID

 AF059292; AY083996; AY083997; AY083997; AJ493061; AK290413; AC099344; BC008348; BC107740; AF041381 

Genbank Nucleotide ID

 AAC31426.1; AAM10783.1; AAM10784.1; AAM10785.1; CAD37950.1; BAF83102.1; AAY14826.1; AAH08348.1; AAI07741.1; AAC14694.1 

Protein Name

 Transcription factor E2F6 

Protein Synonyms/Alias

 E2F-6 

Gene Name

 E2F6 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
43	DGIDLVEKKSKNHIR	ubiquitination	[1]
66	FGAVPQQKKLQEELS	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Inhibitor of E2F-dependent transcription. Binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. Has a preference for the 5'-TTTCCCGC-3' E2F recognition site. E2F6 lacks the transcriptional activation and pocket protein binding domains. Appears to regulate a subset of E2F-dependent genes whose products are required for entry into the cell cycle but not for normal cell cycle progression. May silence expression via the recruitment of a chromatin remodeling complex containing histone H3-K9 methyltransferase activity. Overexpression delays the exit of cells from the S-phase. 

Sequence Annotation

 DNA_BIND 50 129 Potential.
 REGION 130 222 Dimerization (Potential).
 REGION 143 164 Leucine-zipper.
 REGION 173 281 Transcription repression.
 MOTIF 95 129 DEF box.
 MOD_RES 67 67 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Cell cycle; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 281 AA 

Protein Sequence

Gene Ontology

 GO:0071339; C:MLL1 complex; IDA:UniProtKB.
 GO:0005667; C:transcription factor complex; IEA:InterPro.
 GO:0003677; F:DNA binding; TAS:ProtInc.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; TAS:ProtInc.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; TAS:ProtInc.
 GO:0000083; P:regulation of transcription involved in G1/S phase of mitotic cell cycle; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR015633; E2F.
 IPR003316; E2F_TDP.
 IPR015635; Transcription_factor_E2F6.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF02319; E2F_TDP 

SMART

  

PROSITE

  

PRINTS