UniProt Accession

 VPS29_HUMAN; Q9UBQ0; Q502Y5; Q6FIF8; Q6IAH3; Q9H0W0; Q9NRP1; Q9NRU7 

Genbank Protein ID

 AF193795; AF175264; AF168716; AF201936; AF201946; AL136614; CR457182; CR533468; BC000880; BC095446 

Genbank Nucleotide ID

 AAF04596.1; AAF89952.1; AAF87318.1; AAF86872.1; AAF17238.1; CAB66549.1; CAG33463.1; CAG38499.1; AAH00880.1; AAH95446.1 

Protein Name

 Vacuolar protein sorting-associated protein 29 

Protein Synonyms/Alias

 hVPS29; PEP11 homolog; Vesicle protein sorting 29 

Gene Name

 VPS29 

Gene Synonyms/Alias

 DC15; DC7; MDS007 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
77	NLNYPEQKVVTVGQF	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro). 

Sequence Annotation

 METAL 8 8 Zinc 1 (By similarity).
 METAL 10 10 Zinc 1 (By similarity).
 METAL 39 39 Zinc 1 (By similarity).
 METAL 39 39 Zinc 2 (By similarity).
 METAL 62 62 Zinc 2 (By similarity).
 METAL 86 86 Zinc 2 (By similarity).
 METAL 115 115 Zinc 2 (By similarity).
 METAL 117 117 Zinc 1 (By similarity).
 MOD_RES 50 50 N6-acetyllysine.  

Keyword

 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Endosome; Hydrolase; Membrane; Metal-binding; Protein transport; Reference proteome; Transport; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 182 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IDA:LIFEdb.
 GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004647; F:phosphoserine phosphatase activity; IEA:EC.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW. 

Interpro

 IPR024654; Calcineurin-like_PEstase_dom.
 IPR000979; Phosphodiesterase_MJ0936. 

Pfam

 PF12850; Metallophos_2 

SMART

  

PROSITE

  

PRINTS