UniProt Accession

 IGBP1_MOUSE; Q61249 

Genbank Protein ID

 L31652; AJ000633; AJ223156; AJ223157; AJ223158; AJ223159; AJ223160; AJ000634 

Genbank Nucleotide ID

 AAA67891.1; CAA04190.1; CAA11135.1; CAA11135.1; CAA11135.1; CAA11135.1; CAA11135.1; CAA04191.1 

Protein Name

 Immunoglobulin-binding protein 1 

Protein Synonyms/Alias

 Alpha4 phosphoprotein; CD79a-binding protein 1; Lymphocyte signal transduction molecule alpha 4; Protein phosphatase 2/4/6 regulatory subunit; p52 

Gene Name

 Igbp1 

Gene Synonyms/Alias

 Pc52 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
45	TIQDKVSKGLELLEK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Associated to surface IgM-receptor; may be involved in signal transduction. Involved in regulation of the catalytic activity of the phosphatases PP2A, PP4 and PP6 by protecting their partially folded catalytic subunits from degradative polyubiquitination until they associate with regulatory subunits. 

Sequence Annotation

 REPEAT 47 61 UIM.
 REGION 99 203 Interaction with PPP2CA (By similarity).
 REGION 226 291 Interaction with MID1 (By similarity).
 MOD_RES 242 242 N6-acetyllysine (By similarity).  

Keyword

 3D-structure; Acetylation; B-cell activation; Chaperone; Complete proteome; Cytoplasm; Phosphoprotein; Reference proteome; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 340 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008601; F:protein phosphatase type 2A regulator activity; IEA:Compara.
 GO:0042113; P:B cell activation; IEA:UniProtKB-KW.
 GO:0043066; P:negative regulation of apoptotic process; IMP:UniProtKB.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0035308; P:negative regulation of protein dephosphorylation; IDA:UniProtKB.
 GO:0032873; P:negative regulation of stress-activated MAPK cascade; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0035306; P:positive regulation of dephosphorylation; IMP:UniProtKB.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:UniProtKB.
 GO:0060632; P:regulation of microtubule-based movement; IEA:Compara.
 GO:0070555; P:response to interleukin-1; IEA:Compara.
 GO:0034612; P:response to tumor necrosis factor; IEA:Compara. 

Interpro

 IPR007304; TAP42-like. 

Pfam

 PF04177; TAP42 

SMART

  

PROSITE

 PS50330; UIM 

PRINTS