UniProt Accession

 CENPU_MOUSE; Q8C4M7; Q6UNA2; Q9D9U1 

Genbank Protein ID

 AY366362; AK006479; AK050386; AK081703 

Genbank Nucleotide ID

 AAR13082.1; BAB24609.1; BAC34227.1; BAC38300.1 

Protein Name

 Centromere protein U 

Protein Synonyms/Alias

 CENP-U; MLF1-interacting protein 

Gene Name

 Mlf1ip 

Gene Synonyms/Alias

 Cenpu 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
292	LKEAQMLKALKMKNT	acetylation	[1]
292	LKEAQMLKALKMKNT	succinylation	[1]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. Plays an important role in the correct PLK1 localization to the mitotic kinetochores. A scaffold protein responsible for the initial recruitment and maintenance of the kinetochore PLK1 population until its degradation. Involved in transcriptional repression (By similarity). 

Sequence Annotation

 MOTIF 4 21 Nuclear localization signal (Potential).
 MOTIF 295 312 Nuclear localization signal (Potential).
 MOD_RES 74 74 Phosphothreonine; by PLK1 (By
 MOD_RES 106 106 Phosphoserine (By similarity).
 MOD_RES 131 131 Phosphoserine (By similarity).
 MOD_RES 134 134 Phosphoserine (By similarity).
 MOD_RES 136 136 Phosphoserine (By similarity).
 MOD_RES 186 186 Phosphoserine (By similarity).  

Keyword

 Alternative splicing; Centromere; Chromosome; Coiled coil; Complete proteome; Cytoplasm; Kinetochore; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 410 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR025214; NAC_CENP-U. 

Pfam

 PF13097; CENP-U 

SMART

  

PROSITE

  

PRINTS