UniProt Accession

 MMP3_MOUSE; P28862 

Genbank Protein ID

 X66402; X63162 

Genbank Nucleotide ID

 CAA47029.1; CAA44860.1 

Protein Name

 Stromelysin-1 

Protein Synonyms/Alias

 SL-1; EMS-2; Matrix metalloproteinase-3; MMP-3; Transin-1 

Gene Name

 Mmp3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
386	LGLPATVKKIDAAIS	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase. 

Sequence Annotation

 REPEAT 287 336 Hemopexin 1.
 REPEAT 337 383 Hemopexin 2.
 REPEAT 385 433 Hemopexin 3.
 REPEAT 434 477 Hemopexin 4.
 MOTIF 90 97 Cysteine switch (By similarity).
 ACT_SITE 219 219 By similarity.
 METAL 92 92 Zinc 2; in inhibited form (By
 METAL 124 124 Calcium 1 (By similarity).
 METAL 158 158 Calcium 2 (By similarity).
 METAL 168 168 Zinc 1 (By similarity).
 METAL 170 170 Zinc 1 (By similarity).
 METAL 175 175 Calcium 3 (By similarity).
 METAL 176 176 Calcium 3; via carbonyl oxygen (By
 METAL 178 178 Calcium 3; via carbonyl oxygen (By
 METAL 180 180 Calcium 3; via carbonyl oxygen (By
 METAL 183 183 Zinc 1 (By similarity).
 METAL 190 190 Calcium 2; via carbonyl oxygen (By
 METAL 192 192 Calcium 2; via carbonyl oxygen (By
 METAL 194 194 Calcium 2 (By similarity).
 METAL 196 196 Zinc 1 (By similarity).
 METAL 198 198 Calcium 3 (By similarity).
 METAL 199 199 Calcium 1 (By similarity).
 METAL 201 201 Calcium 1 (By similarity).
 METAL 201 201 Calcium 3 (By similarity).
 METAL 218 218 Zinc 2; catalytic (By similarity).
 METAL 222 222 Zinc 2; catalytic (By similarity).
 METAL 228 228 Zinc 2; catalytic (By similarity).
 METAL 297 297 Calcium 4; via carbonyl oxygen (By
 METAL 389 389 Calcium 4; via carbonyl oxygen (By
 METAL 438 438 Calcium 4; via carbonyl oxygen (By
 CARBOHYD 120 120 N-linked (GlcNAc...) (Potential).
 DISULFID 290 477 By similarity.  

Keyword

 Calcium; Collagen degradation; Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome; Repeat; Secreted; Signal; Zinc; Zymogen. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 477 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0043231; C:intracellular membrane-bounded organelle; IEA:Compara.
 GO:0005578; C:proteinaceous extracellular matrix; IEA:UniProtKB-SubCell.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0071230; P:cellular response to amino acid stimulus; IDA:MGI.
 GO:0030574; P:collagen catabolic process; IEA:UniProtKB-KW.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
 GO:0030334; P:regulation of cell migration; IMP:MGI. 

Interpro

 IPR000585; Hemopexin-like_dom.
 IPR018487; Hemopexin-like_repeat.
 IPR018486; Hemopexin_CS.
 IPR024079; MetalloPept_cat_dom.
 IPR001818; Pept_M10_metallopeptidase.
 IPR021190; Pept_M10A.
 IPR016293; Pept_M10A_Metazoans.
 IPR021158; Pept_M10A_Zn_BS.
 IPR006026; Peptidase_Metallo.
 IPR002477; Peptidoglycan-bd-like. 

Pfam

 PF00045; Hemopexin
 PF00413; Peptidase_M10
 PF01471; PG_binding_1 

SMART

 SM00120; HX
 SM00235; ZnMc 

PROSITE

 PS00546; CYSTEINE_SWITCH
 PS00024; HEMOPEXIN
 PS51642; HEMOPEXIN_2
 PS00142; ZINC_PROTEASE 

PRINTS

 PR00138; MATRIXIN.