| Tag | Content |
|---|
| CPLM ID | CPLM-003932 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Peroxisomal carnitine O-octanoyltransferase |
Protein Synonyms/Alias | COT |
Gene Name | Crot |
Gene Synonyms/Alias | Cot |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 69 | VGKTLHQKLLERAKG | acetylation | [1] | | 406 | STFTSFGKKLTKKEA | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Beta-oxidation of fatty acids. The highest activity concerns the C6 to C10 chain length substrate. |
Sequence Annotation | REGION 405 417 Coenzyme A binding (By similarity).
MOTIF 610 612 Microbody targeting signal (Potential).
ACT_SITE 327 327 Proton acceptor (By similarity).
BINDING 439 439 Carnitine (By similarity).
BINDING 442 442 Coenzyme A (By similarity).
BINDING 452 452 Carnitine (By similarity).
BINDING 505 505 Carnitine (By similarity). |
Keyword | Acyltransferase; Complete proteome; Fatty acid metabolism; Lipid metabolism; Peroxisome; Reference proteome; Transferase; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 612 AA |
Protein Sequence | MENQLAKSIE ERTFQYQDSL PPLPVPSLEE SLKKYLESVK PFANEDEYKK TEEIVQKFQD 60
GVGKTLHQKL LERAKGKRNW LEEWWLNVAY LDVRIPSQLN VNFVGPSPHF EHYWPAREGT 120
QLERGSILLW HNLNYWQLLR REKLPVHKSG NTPLDMNQFR MLFSTCKVPG ITRDSIMNYF 180
KTESEGHCPT HIAVLCRGRA FVFDVLHDGC LITPPELLRQ LTYIYQKCWN EPVGPSIAAL 240
TSEERTRWAK AREYLIGLDP ENLTLLEKIQ SSLFVYSIED TSPHATPENF SQVFEMLLGG 300
DPAVRWGDKS YNLISFANGI FGCSCDHAPY DAMLMVNIAH YVDEKLLETE GRWKGSEKVR 360
DIPLPEELAF TVDEKILNDV YQAKAQHLKA ASDLQIAAST FTSFGKKLTK KEALHPDTFI 420
QLALQLAYYR LHGRPGCCYE TAMTRYFYHG RTETVRSCTV EAVRWCQSMQ DPSASLLERQ 480
QKMLDAFAKH NKMMRDCSHG KGFDRHLLGL LLIAKEEGLP VPELFEDPLF SRSGGGGNFV 540
LSTSLVGYLR IQGVVVPMVH NGYGFFYHIR DDRFVVTCSS WRSCLETDAE KLVEMIFHAF 600
HDMIHLMNTA HL 612 |
Gene Ontology | GO:0005777; C:peroxisome; IDA:RGD. GO:0008458; F:carnitine O-octanoyltransferase activity; IDA:RGD. GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway. GO:0006091; P:generation of precursor metabolites and energy; ISS:UniProtKB. GO:0015909; P:long-chain fatty acid transport; TAS:RGD. GO:0051791; P:medium-chain fatty acid metabolic process; ISS:UniProtKB. GO:0001579; P:medium-chain fatty acid transport; TAS:RGD. GO:0042493; P:response to drug; IDA:RGD. GO:0010243; P:response to organic nitrogen; IEP:RGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
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