UniProt Accession

 DDA1_HUMAN; Q9BW61 

Genbank Protein ID

 DQ090952; AY563006; CH471106; BC000615 

Genbank Nucleotide ID

 AAZ41375.1; AAS66629.1; EAW84593.1; AAH00615.1 

Protein Name

 DET1- and DDB1-associated protein 1 

Protein Synonyms/Alias

 Placenta cross-immune reaction antigen 1; PCIA-1 

Gene Name

 DDA1 

Gene Synonyms/Alias

 C19orf58; PCIA1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MADFLKGLPVYNK	ubiquitination	[1, 2]
13	KGLPVYNKSNFSRFH	ubiquitination	[2, 3]
26	FHADSVCKASNRRPS	ubiquitination	[2, 3]
65	YLHQQWDKKNAAKKR	acetylation	[3, 4]
65	YLHQQWDKKNAAKKR	ubiquitination	[2]
66	LHQQWDKKNAAKKRD	ubiquitination	[2]
71	DKKNAAKKRDQEQVE	ubiquitination	[2]

Reference

 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD- E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins. 

Sequence Annotation

 MOD_RES 33 33 Phosphoserine.
 MOD_RES 95 95 Phosphoserine.  

Keyword

 Complete proteome; Phosphoprotein; Reference proteome; Ubl conjugation pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 102 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR018276; Ub_ligase_Det1/DDB1-complexing. 

Pfam

 PF10172; DDA1 

SMART

  

PROSITE

  

PRINTS