UniProt Accession

 CYSH_ECOLI; P17854; Q2MA67 

Genbank Protein ID

 Y07525; M23008; U29579; U00096; AP009048 

Genbank Nucleotide ID

 CAA68817.1; AAA23652.1; AAA69272.1; AAC75804.1; BAE76839.1 

Protein Name

 Phosphoadenosine phosphosulfate reductase 

Protein Synonyms/Alias

 3'-phosphoadenylylsulfate reductase; PAPS reductase, thioredoxin dependent; PAPS sulfotransferase; PAdoPS reductase 

Gene Name

 cysH 

Gene Synonyms/Alias

 b2762; JW2732 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
14	NALNELPKVDRILAL	acetylation	[1]
30	ETNAELEKLDAEGRV	acetylation	[1]
96	FIDELTDKLKLNLKV	acetylation	[1]
98	DELTDKLKLNLKVYR	acetylation	[1]
102	DKLKLNLKVYRATES	acetylation	[1]
119	WQEARYGKLWEQGVE	acetylation	[1]
130	QGVEGIEKYNDINKV	acetylation	[1]
136	EKYNDINKVEPMNRA	acetylation	[1]
145	EPMNRALKELNAQTW	acetylation	[1]
178	AIQRGVFKVLPIIDW	acetylation	[1]
196	TIYQYLQKHGLKYHP	acetylation	[1]
200	YLQKHGLKYHPLWDE	acetylation	[1]
220	GDTHTTRKWEPGMAE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Reduction of activated sulfate into sulfite. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 244 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004604; F:phosphoadenylyl-sulfate reductase (thioredoxin) activity; IEA:HAMAP.
 GO:0019344; P:cysteine biosynthetic process; IEA:InterPro.
 GO:0070814; P:hydrogen sulfide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
 GO:0019379; P:sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin); IEA:HAMAP. 

Interpro

 IPR004511; PAPS/APS_Rdtase.
 IPR002500; PAPS_reduct.
 IPR011800; PAPS_reductase_CysH.
 IPR014729; Rossmann-like_a/b/a_fold. 

Pfam

 PF01507; PAPS_reduct 

SMART

  

PROSITE

  

PRINTS