UniProt Accession

 ASGR2_MOUSE; P24721 

Genbank Protein ID

 X53042; BC011197 

Genbank Nucleotide ID

 CAA37211.1; AAH11197.1 

Protein Name

 Asialoglycoprotein receptor 2 

Protein Synonyms/Alias

 ASGP-R 2; ASGPR 2; Hepatic lectin 2; HL-2; mHL-2 

Gene Name

 Asgr2 

Gene Synonyms/Alias

 Asgr-2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
3	*****MEKDCQDIQQ	ubiquitination	[1]
41	RIENPHWKGQPLSRP	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Mediates the endocytosis of plasma glycoproteins to which the terminal sialic acid residue on their complex carbohydrate moieties has been removed. The receptor recognizes terminal galactose and N-acetylgalactosamine units. After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. The receptor then returns to the cell membrane surface. 

Sequence Annotation

 DOMAIN 169 295 C-type lectin.
 MOD_RES 13 13 Phosphoserine.
 LIPID 54 54 S-palmitoyl cysteine (By similarity).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 165 165 N-linked (GlcNAc...) (Potential).
 CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
 DISULFID 170 181 By similarity.
 DISULFID 198 293 By similarity.
 DISULFID 271 285 By similarity.  

Keyword

 Calcium; Complete proteome; Disulfide bond; Endocytosis; Glycoprotein; Lectin; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Receptor; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 301 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030246; F:carbohydrate binding; IEA:InterPro.
 GO:0030282; P:bone mineralization; IEA:Compara.
 GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
 GO:0009100; P:glycoprotein metabolic process; IMP:MGI.
 GO:0055088; P:lipid homeostasis; IMP:MGI.
 GO:0031647; P:regulation of protein stability; IMP:MGI. 

Interpro

 IPR001304; C-type_lectin.
 IPR016186; C-type_lectin-like.
 IPR018378; C-type_lectin_CS.
 IPR016187; C-type_lectin_fold.
 IPR005640; Lectin_N. 

Pfam

 PF00059; Lectin_C
 PF03954; Lectin_N 

SMART

 SM00034; CLECT 

PROSITE

 PS00615; C_TYPE_LECTIN_1
 PS50041; C_TYPE_LECTIN_2 

PRINTS