UniProt Accession

 I3NI32_HUMAN; I3NI32 

Genbank Protein ID

 AC009087; AC009127 

Genbank Nucleotide ID

  

Protein Name

 Dihydroorotate dehydrogenase (quinone), mitochondrial 

Protein Synonyms/Alias

  

Gene Name

 DHODH 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
169	ARQQKQAKLTEDGLP	ubiquitination	[1]
183	PLGVNLGKNKTSVDA	ubiquitination	[1]
185	GVNLGKNKTSVDAAE	ubiquitination	[2]
226	GLRSLQGKAELRRLL	ubiquitination	[1]
235	ELRRLLTKVLQERDG	ubiquitination	[1]
306	ETGGLSGKPLRDLST	ubiquitination	[1, 2]
342	SGQDALEKIRAGASL	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 393 AA 

Protein Sequence

Gene Ontology

 GO:0016020; C:membrane; IEA:InterPro.
 GO:0004158; F:dihydroorotate oxidase activity; IEA:InterPro.
 GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; IEA:InterPro.
 GO:0006222; P:UMP biosynthetic process; IEA:InterPro. 

Interpro

 IPR013785; Aldolase_TIM.
 IPR012135; Dihydroorotate_DH_1_2.
 IPR005719; Dihydroorotate_DH_2.
 IPR001295; Dihydroorotate_DH_CS. 

Pfam

 PF01180; DHO_dh 

SMART

  

PROSITE

 PS00911; DHODEHASE_1
 PS00912; DHODEHASE_2 

PRINTS