UniProt Accession

 CD226_HUMAN; Q15762; B2R818 

Genbank Protein ID

 U56102; AJ537553; AK313199; AC011930; AC090231; AC091137; CH471117; BC074787 

Genbank Nucleotide ID

 AAC50560.1; CAD61184.1; BAG36015.1; EAW66515.1; AAH74787.1 

Protein Name

 CD226 antigen 

Protein Synonyms/Alias

 DNAX accessory molecule 1; DNAM-1; CD226 

Gene Name

 CD226 

Gene Synonyms/Alias

 DNAM1 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
167	VQAVRWEKIQPRQID	ubiquitination	[1]
295	TESWDTQKAPNNYRS	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. 

Sequence Annotation

 DOMAIN 19 126 Ig-like C2-type 1.
 DOMAIN 135 239 Ig-like C2-type 2.
 MOD_RES 322 322 Phosphotyrosine.
 CARBOHYD 32 32 N-linked (GlcNAc...) (Potential).
 CARBOHYD 83 83 N-linked (GlcNAc...) (Potential).
 CARBOHYD 90 90 N-linked (GlcNAc...) (Potential).
 CARBOHYD 97 97 N-linked (GlcNAc...) (Potential).
 CARBOHYD 147 147 N-linked (GlcNAc...) (Potential).
 CARBOHYD 186 186 N-linked (GlcNAc...) (Potential).
 CARBOHYD 198 198 N-linked (GlcNAc...) (Potential).
 CARBOHYD 231 231 N-linked (GlcNAc...) (Potential).
 DISULFID 37 108 Potential.
 DISULFID 152 222 Potential.  

Keyword

 Cell adhesion; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin domain; Membrane; Phosphoprotein; Polymorphism; Receptor; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 336 AA 

Protein Sequence

Gene Ontology

 GO:0009986; C:cell surface; IDA:BHF-UCL.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0045121; C:membrane raft; TAS:BHF-UCL.
 GO:0007155; P:cell adhesion; TAS:ProtInc.
 GO:0008037; P:cell recognition; TAS:BHF-UCL.
 GO:0001816; P:cytokine production; IEA:Compara.
 GO:0060369; P:positive regulation of Fc receptor mediated stimulatory signaling pathway; IDA:BHF-UCL.
 GO:0002891; P:positive regulation of immunoglobulin mediated immune response; IDA:BHF-UCL.
 GO:0033005; P:positive regulation of mast cell activation; IDA:BHF-UCL.
 GO:0002860; P:positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target; IMP:BHF-UCL.
 GO:0007165; P:signal transduction; TAS:ProtInc. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003598; Ig_sub2.
 IPR013106; Ig_V-set. 

Pfam

 PF07686; V-set 

SMART

 SM00408; IGc2 

PROSITE

 PS50835; IG_LIKE 

PRINTS