CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029716
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 HLA class II histocompatibility antigen, DM alpha chain 
Protein Synonyms/Alias
  
Gene Name
 HLA-DMA 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119IGPKLDGKIPVSRGFubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Immunity; Membrane; MHC II; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MGHEQNQGAA LLQMLPLLWL LPHSWAVPEA PTPMWPDDLQ NHTFLHTVYC QDGSPSVGLS 60
EAYDEDQLFF FDFSQNTRVP RLPEFADWAQ EQGDAPAILF DKEFCEWMIQ QIGPKLDGKI 120
PVSRGFPIAE VFTLKPLEFG KPNTLVCFVS NLFPPMLTVN WQHHSIPVEG FGPTFVSAVD 180
GLSFQAFSYL NFTPEPSDIF SCIVTHEIDR YTAIAYWVPR NALPSDLLEN VLCGVAFGLG 240
VLGIIVGIVL IIYFRKPCSG D 261 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
 GO:0002504; P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; IEA:InterPro. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR014745; MHC_II_a/b_N.
 IPR001003; MHC_II_a_N. 
Pfam
 PF07654; C1-set
 PF00993; MHC_II_alpha 
SMART
 SM00407; IGc1
 SM00920; MHC_II_alpha 
PROSITE
 PS50835; IG_LIKE
 PS00290; IG_MHC 
PRINTS