| Tag | Content |
|---|
| CPLM ID | CPLM-002093 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Tubulin alpha chain |
Protein Synonyms/Alias | |
Gene Name | |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Trypanosoma brucei rhodesiense |
NCBI Taxa ID | 31286 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 40 | DGAMPSDKTIGVEDD | acetylation | [1] |
|
Reference | [1] Subpellicular and flagellar microtubules of Trypanosoma brucei are extensively glutamylated. Schneider A, Plessmann U, Weber K. J Cell Sci. 1997 Feb;110 ( Pt 4):431-7. [ PMID: 9067595] |
Functional Description | Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. |
Sequence Annotation | NP_BIND 142 148 GTP (Potential).
MOD_RES 40 40 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 451 AA |
Protein Sequence | MREAICIHIG QAGCQVGNAC WELFCLEHGI QPDGAMPSDK TIGVEDDAFN TFFSETGAGK 60
HVPRAVFLDL EPTVVDEVRT GTYRQLFHPE QLISGKEDAA NNYARGHYTI GKEIVDLCLD 120
RIRKLADNCT GLQGFLVYHA VGGGTGSGLG ALLLERLSVD YGKKSKLGYT VYPSPQVSTA 180
VVEPYNSVLS THSLLEHTDV AAMLDNEAIY DLTRRNLDIE RPTYTNLNRL IGQVVSSLTA 240
SLRFDGALNV DLTEFQTNLV PYPRIHFVLT SYAPVISAEK AYHEQLSVSE ISNAVFEPAS 300
MMTKCDPRHG KYMACCLMYR GDVVPKDVNA AVATIKTKRT IQFVDWSPTG FKCGINYQPP 360
TVVPGGDLAK VQRAVCMIAN STAIAEVFAR IDHKFDLMYS KRAFVHWYVG EGMEEGEFSE 420
AREDLAALEK DYEEVGAESA DMDGEEDVEE Y 451 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-KW. GO:0005874; C:microtubule; IEA:UniProtKB-KW. GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro. GO:0007017; P:microtubule-based process; IEA:InterPro. GO:0051258; P:protein polymerization; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |