UniProt Accession

 DMB_MOUSE; P35737 

Genbank Protein ID

 X62743; U35323 

Genbank Nucleotide ID

 CAA44605.1; AAA98931.1 

Protein Name

 Class II histocompatibility antigen, M beta 1 chain 

Protein Synonyms/Alias

 H2-M beta 1 chain 

Gene Name

 H2-DMb1 

Gene Synonyms/Alias

 H-2Mb1; Mb 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
82	NFSRILNKEESLLQR	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides. 

Sequence Annotation

 DOMAIN 114 204 Ig-like C1-type.
 REGION 19 112 Beta-1.
 REGION 113 207 Beta-2.
 REGION 208 218 Connecting peptide (Potential).
 MOTIF 248 251 YXXZ motif.
 CARBOHYD 75 75 N-linked (GlcNAc...) (Potential).
 DISULFID 29 97 By similarity.
 DISULFID 135 192 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Endosome; Glycoprotein; Immunity; Lysosome; Membrane; MHC II; Reference proteome; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 261 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
 GO:0019886; P:antigen processing and presentation of exogenous peptide antigen via MHC class II; IDA:MGI.
 GO:0051085; P:chaperone mediated protein folding requiring cofactor; IDA:MGI.
 GO:0006955; P:immune response; IEA:InterPro. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR014745; MHC_II_a/b_N.
 IPR000353; MHC_II_b_N. 

Pfam

 PF07654; C1-set
 PF00969; MHC_II_beta 

SMART

 SM00407; IGc1
 SM00921; MHC_II_beta 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS