CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Synaptotagmin-like protein 3 
Protein Synonyms/Alias
 Exophilin-6 
Gene Name
 SYTL3 
Gene Synonyms/Alias
 SLP3 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
379PTFQETLKYQVAPAQubiquitination[1]
439PLRAKAEKYEDSVPQubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
 May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity). 
Sequence Annotation
 DOMAIN 4 123 RabBD.
 DOMAIN 308 412 C2 1.
 DOMAIN 467 571 C2 2.
 MOD_RES 243 243 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 610 AA 
Protein Sequence
MAQEIDLSAL KELEREAILQ VLYRDQAVQN TEEERTRKLK THLQHLRWKG AKNTDWEHKE 60
KCCARCQQVL GFLLHRGAVC RGCSHRVCAQ CRVFLRGTHA WKCTVCFEDR NVKIKTGEWF 120
YEERAKKFPT GGKHETVGGQ LLQSYQKLSK ISVVPPTPPP VSESQCSRSP GRLQEFGQFR 180
GFNKSVENLF LSLATHVKKL SKSQNDMTSE KHLLATGPRQ CVGQTERRSQ SDTAVNVTTR 240
KVSAPDILKP LNQEDPKCST NPILKQQNLP SSPAPSTIFS GGFRHGSLIS IDSTCTEMGN 300
FDNANVTGEI EFAIHYCFKT HSLEICIKAC KNLAYGEEKK KKCNPYVKTY LLPDRSSQGK 360
RKTGVQRNTV DPTFQETLKY QVAPAQLVTR QLQVSVWHLG TLARRVFLGE VIIPLATWDF 420
EDSTTQSFRW HPLRAKAEKY EDSVPQSNGE LTVRAKLVLP SRPRKLQEAQ EGTDQPSLHG 480
QLCLVVLGAK NLPVRPDGTL NSFVKGCLTL PDQQKLRLKS PVLRKQACPQ WKHSFVFSGV 540
TPAQLRQSSL ELTVWDQALF GMNDRLLGGT RLGSKGDTAV GGDACSLSKL QWQKVLSSPN 600
LWTDMTLVLH 610 
Gene Ontology
 GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
 GO:0019897; C:extrinsic to plasma membrane; IEA:Compara.
 GO:0005544; F:calcium-dependent phospholipid binding; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006886; P:intracellular protein transport; IEA:InterPro. 
Interpro
 IPR000008; C2_Ca-dep.
 IPR008973; C2_Ca/lipid-bd_dom_CaLB.
 IPR018029; C2_membr_targeting.
 IPR010911; Rab-bd_domain.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF00168; C2 
SMART
 SM00239; C2 
PROSITE
 PS50004; C2
 PS50916; RABBD 
PRINTS