| Tag | Content |
|---|
| CPLM ID | CPLM-014846 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | H/ACA ribonucleoprotein complex subunit 1 |
Protein Synonyms/Alias | Nucleolar protein family A member 1; snoRNP protein GAR1 |
Gene Name | Gar1 |
Gene Synonyms/Alias | Nola1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 152 | KFYIDPYKLLPLQRF | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme (By similarity). |
Sequence Annotation | REGION 4 59 RGG-box 1.
REGION 171 226 RGG-box 2. |
Keyword | Complete proteome; Nucleus; Reference proteome; Repeat; Ribonucleoprotein; Ribosome biogenesis; RNA-binding; rRNA processing. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 226 AA |
Protein Sequence | MSFRGGGRGG FNRGGGGGGF NRGGGSNNHF RGGGGGGGGG GNFRGGGRGG FGRGGGRGGF 60
NKFQDQGPPE RVVLLGEFMH PCEDDIVCKC TTEENKVPYF NAPVYLENKE QIGKVDEIFG 120
QLRDFYFSVK LSENMKASSF KKLQKFYIDP YKLLPLQRFL PRPPGEKGPP RGGGGGGGGG 180
RGGRGGGRGG GGRGGGRGGG FRGGRGGGGG FRGGRGGGGG FRGRGH 226 |
Gene Ontology | GO:0031429; C:box H/ACA snoRNP complex; IEA:InterPro. GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell. GO:0009982; F:pseudouridine synthase activity; IEA:InterPro. GO:0030515; F:snoRNA binding; IEA:InterPro. GO:0006364; P:rRNA processing; IEA:UniProtKB-KW. GO:0031120; P:snRNA pseudouridine synthesis; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |