CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005593
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Phospholipase A-2-activating protein 
Protein Synonyms/Alias
 PLA2P; PLAP 
Gene Name
 Plaa 
Gene Synonyms/Alias
 Plap 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
311TASAEEIKAFERELSubiquitination[1]
325SQATIDSKTGDLGDIubiquitination[1]
393ANQQTSGKVLYEGKEubiquitination[1]
456KFIIDNTKGQTLGLGubiquitination[1]
554NPTQILGKLKELNGTubiquitination[1]
622DILRLSIKHPNVNENubiquitination[1]
651NLLNPKGKPANQLLAacetylation[2]
651NLLNPKGKPANQLLAsuccinylation[2]
772LGVDSQIKKYVSVSEubiquitination[1]
773GVDSQIKKYVSVSEPacetylation[3]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 
Functional Description
 Involved in the maintenance of ubiquitin levels (By similarity). 
Sequence Annotation
 REPEAT 17 56 WD 1.
 REPEAT 63 107 WD 2.
 REPEAT 110 148 WD 3.
 REPEAT 149 188 WD 4.
 REPEAT 190 227 WD 5.
 REPEAT 229 268 WD 6.
 REPEAT 270 307 WD 7.
 DOMAIN 366 465 PFU.
 DOMAIN 533 793 PUL.
 REPEAT 546 588 ARM 1.
 REPEAT 589 620 ARM 2.
 REPEAT 621 668 ARM 3.
 REPEAT 669 714 ARM 4.
 REPEAT 715 754 ARM 5.
 REPEAT 755 794 ARM 6.
 MOD_RES 529 529 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; Complete proteome; Reference proteome; Repeat; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 794 AA 
Protein Sequence
MASGASRYRL SCSLPGHELD VRGLVCCLYP PGAFVSVSRD RTTRLWAPDS PNRGFTEMHC 60
MSGHSNFVSC VCIIPSSDIY PHGLIATGGN DHNICIFSLD SPMPLYILKG HKDTVCSLSS 120
GKFGTLLSGS WDTTAKVWLN DKCMMTLQGH TAAVWAVKIL PEQGLMLTGS ADKTIKLWKA 180
GRCERTFLGH EDCVRGLAIL SETEFLSCAN DASIRRWQIT GECLEVYFGH TNYIYSISVF 240
PNSKDFVTTA EDRSLRIWKH GECAQTIRLP AQSIWCCCVL ENGDIVVGAS DGIIRVFTES 300
EERTASAEEI KAFERELSQA TIDSKTGDLG DINAEQLPGR EHLSEPGTRE GQTRLIRDGE 360
RVEAYQWSVS DGRWIKIGDV VGSSGANQQT SGKVLYEGKE FDYVFSIDVN EGGPSYKLPY 420
NVSDDPWLVA YNFLQKNDLN PMFLDQVAKF IIDNTKGQTL GLGNTSFSDP FTGGGRYVPG 480
TSGPSNTVQT ADPFTGAGRY MPGSAGMDTT MTGVDPFTGN SAYRSAASKT VNIYFPKKEA 540
LTFDQANPTQ ILGKLKELNG TAPEEKKLTE DDLVLLEKIL SLICNNSSEK PTAQQLQILW 600
KAINWPEDIV FPALDILRLS IKHPNVNENF CNEKGDQFSS HLINLLNPKG KPANQLLALR 660
TFCNCFVSQA GQKLMMSQRE SLMSHAIELK SGSNKNIHIA LATLTLNYSV CFHKDHNIEG 720
KAQCLSVIST ILEVVQDLEA TFRLLVALGT LISDDSNAIQ LAKSLGVDSQ IKKYVSVSEP 780
AKVSECCRLV LHLL 794 
Gene Ontology
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0016005; F:phospholipase A2 activator activity; IDA:MGI.
 GO:0006954; P:inflammatory response; IDA:MGI. 
Interpro
 IPR015155; PLAA_fam_Ub-bd_PFU.
 IPR013535; PUL.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF09070; PFU
 PF08324; PUL
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS50176; ARM_REPEAT
 PS51394; PFU
 PS51396; PUL
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS