CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011513
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Solute carrier family 2, facilitated glucose transporter member 3 
Protein Synonyms/Alias
 Glucose transporter type 3, brain; GLUT-3 
Gene Name
 Slc2a3 
Gene Synonyms/Alias
 Glut-3; Glut3 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
217RFLLINRKEEDQATEacetylation[1]
217RFLLINRKEEDQATEubiquitination[2]
487LNSMQPVKETPGNA*ubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Facilitative glucose transporter. Probably a neuronal glucose transporter. 
Sequence Annotation
 REGION 277 279 Defines substrate specificity (By
 CARBOHYD 43 43 N-linked (GlcNAc...) (Potential).  
Keyword
 Complete proteome; Glycoprotein; Membrane; Reference proteome; Sugar transport; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 493 AA 
Protein Sequence
MGTAKVTPSL VFAVTVATIG SFQFGYNTGV INAPETIIKD FLNYTLEERL EDLPREGLLT 60
TLWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLI AILGGCLMGF AKIAESVEML 120
ILGRLIIGIF CGLCTGFVPM YIGEVSPTAL RGAFGTLNQL GIVVGILVAQ VFGLDFILGS 180
EELWPGLLGL TIIPAILQSA ALPFCPESPR FLLINRKEED QATEILQRLW GTPDVIQEIQ 240
EMKDESIRMS QEKQVTVLEL FKSPSYFQPL LISVVLQLSQ QFSGINAVFY YSTGIFQDAG 300
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT ISLLLKDEYE 360
AMSFVCIVAI LVYVAFFEIG PGPIPWFIVA ELFSQGPRPA AMAVAGCSNW TSNFLVGMFF 420
PSAAAYLGAY VFIIFAAFLV FFLIFTSFKV PETKGRTFED ITRAFEGQAH SGKGSAGVEL 480
NSMQPVKETP GNA 493 
Gene Ontology
 GO:0005901; C:caveola; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0030672; C:synaptic vesicle membrane; IDA:RGD.
 GO:0055056; F:D-glucose transmembrane transporter activity; IDA:UniProtKB.
 GO:0033300; F:dehydroascorbic acid transporter activity; IDA:UniProtKB.
 GO:0016936; F:galactoside binding; IDA:RGD.
 GO:0005536; F:glucose binding; IDA:RGD.
 GO:0033222; F:xylose binding; IDA:RGD.
 GO:0046323; P:glucose import; IDA:RGD.
 GO:0043066; P:negative regulation of apoptotic process; IDA:RGD.
 GO:0009749; P:response to glucose stimulus; IEP:RGD. 
Interpro
 IPR002945; Glc_transpt_3.
 IPR020846; MFS_dom.
 IPR016196; MFS_dom_general_subst_transpt.
 IPR005828; Sub_transporter.
 IPR003663; Sugar/inositol_transpt.
 IPR005829; Sugar_transporter_CS. 
Pfam
 PF00083; Sugar_tr 
SMART
  
PROSITE
 PS50850; MFS
 PS00216; SUGAR_TRANSPORT_1
 PS00217; SUGAR_TRANSPORT_2 
PRINTS
 PR01192; GLUCTRSPORT3.
 PR00171; SUGRTRNSPORT.