CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021547
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Actin-related protein 5 
Protein Synonyms/Alias
 hARP5; Sarcoma antigen NY-SAR-16 
Gene Name
 ACTR5 
Gene Synonyms/Alias
 ARP5 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
175LFSFYHNKPKNSMCSubiquitination[1]
229LQRLLQLKYPGHLAAubiquitination[1]
275YYENNVHKMQLPFSSubiquitination[1]
283MQLPFSSKLLGSTLTubiquitination[1, 2]
294STLTSEEKQERRQQQubiquitination[1]
509GMKARMEKELLEMRPubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. Involved in DNA double-strand break repair and UV-damage excision repair. 
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; DNA damage; DNA recombination; DNA repair; Nucleus; Polymorphism; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 607 AA 
Protein Sequence
MAANVFPFRD ARAAPDPVLE AGPVAHGPLP VPLVLDNGSF QVRAGWACPG QDPGPEPRLQ 60
FRAVCARGRG GARGASGPQV GNALGSLEPL RWMLRSPFDR NVPVNLELQE LLLDYSFQHL 120
GVSSQGCVDH PIVLTEAVCN PLYSRQMMSE LLFECYGIPK VAYGIDSLFS FYHNKPKNSM 180
CSGLIISSGY QCTHVLPILE GRLDAKNCKR INLGGSQAAG YLQRLLQLKY PGHLAAITLS 240
RMEEILHEHS YIAEDYVEEL HKWRCPDYYE NNVHKMQLPF SSKLLGSTLT SEEKQERRQQ 300
QLRRLQELNA RRREEKLQLD QERLDRLLYV QELLEDGQMD QFHKALIELN MDSPEELQSY 360
IQKLSIAVEQ AKQKILQAEV NLEVDVVDSK PETPDLEQLE PSLEDVESMN DFDPLFSEET 420
PGVEKPVTTV QPVFNLAAYH QLFVGTERIR APEIIFQPSL IGEEQAGIAE TLQYILDRYP 480
KDIQEMLVQN VFLTGGNTMY PGMKARMEKE LLEMRPFRSS FQVQLASNPV LDAWYGARDW 540
ALNHLDDNEV WITRKEYEEK GGEYLKEHCA SNIYVPIRLP KQASRSSDAQ ASSKGSAAGG 600
GGAGEQA 607 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0031011; C:Ino80 complex; IDA:UniProtKB.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
 GO:0006302; P:double-strand break repair; IMP:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0070914; P:UV-damage excision repair; IMP:UniProtKB. 
Interpro
 IPR004000; Actin-related.
 IPR004001; Actin_CS. 
Pfam
 PF00022; Actin 
SMART
 SM00268; ACTIN 
PROSITE
 PS00432; ACTINS_2 
PRINTS