CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030178
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Importin-9 
Protein Synonyms/Alias
 cDNA, FLJ93856, Homo sapiens RAN binding protein 9 (RANBP9), mRNA 
Gene Name
 RANBP9 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
119YMREWRTKIQAQIDRubiquitination[1, 2]
176LEELASIKNRQRIQKubiquitination[1, 2, 3, 4, 5]
183KNRQRIQKLVLAGRMubiquitination[1]
216PNLLFTLKVRQFIEMubiquitination[1, 5, 6]
416CGKNTANKKMLKDAFubiquitination[5]
420TANKKMLKDAFSLLAubiquitination[5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 500 AA 
Protein Sequence
MGIGLSAQGV NMNRLPGWDK HSYGYHGDDG HSFCSSGTGQ PYGPTFTTGD VIGCCVNLIN 60
NTCFYTKNGH SLGIAFTDLP PNLYPTVGLQ TPGEVVDANF GQHPFVFDIE DYMREWRTKI 120
QAQIDRFPIG DREGEWQTMI QKMVSSYLVH HGYCATAEAF ARSTDQTVLE ELASIKNRQR 180
IQKLVLAGRM GEAIETTQQL YPSLLERNPN LLFTLKVRQF IEMVNGTDSE VRCLGGRSPK 240
SQDSYPVSPR PFSSPSMSPS HGMNIHNLAS GKGSTAHFSG FESCSNGVIS NKAHQSYCHS 300
NKHQSSNLNV PELNSINMSR SQQVNNFTSN DVDMETDHYS NGVGETSSNG FLNGSSKHDH 360
EMEDCDTEME VDSSQLRRQL CGGSQAAIER MIHFGRELQA MSEQLRRDCG KNTANKKMLK 420
DAFSLLAYSD PWNSPVGNQL DPIQREPVCS ALNSAILETH NLPKQPPLAL AMGQATQCLG 480
LMARSGIGSC AFATVEDYLH 500 
Gene Ontology
  
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013144; CRA_dom.
 IPR024964; CTLH/CRA.
 IPR006595; CTLH_C.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF10607; CLTH
 PF08513; LisH
 PF00622; SPRY 
SMART
 SM00757; CRA
 SM00668; CTLH
 SM00667; LisH
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50897; CTLH
 PS50896; LISH 
PRINTS