| Tag | Content |
|---|
| CPLM ID | CPLM-024656 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Canalicular multispecific organic anion transporter 2 |
Protein Synonyms/Alias | ATP-binding cassette sub-family C member 3; Multidrug resistance-associated protein 3 |
Gene Name | Abcc3 |
Gene Synonyms/Alias | Cmoat2; Mrp3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 251 | SEEDCSHKVVQRLLE | ubiquitination | [1] | | 288 | GEDAVLLKPRPKSKQ | ubiquitination | [1] | | 400 | LVITNSVKRESTVGE | ubiquitination | [1] | | 488 | KFKDSRIKLMSEILN | ubiquitination | [1] | | 498 | SEILNGIKVLKLYAW | ubiquitination | [1] | | 501 | LNGIKVLKLYAWEPS | ubiquitination | [1] | | 717 | FGQPMNPKRYQQALE | ubiquitination | [1] | | 802 | PEGVLAGKTRVLVTH | ubiquitination | [1] | | 926 | KHTNSLEKEALVTKT | ubiquitination | [1] | | 934 | EALVTKTKETGALIK | ubiquitination | [1] | | 941 | KETGALIKEEIAETG | ubiquitination | [1] | | 1167 | YGRIQDFKVLSDTKV | ubiquitination | [1] | | 1173 | FKVLSDTKVDNNQKS | ubiquitination | [1] | | 1263 | VKEYSKTKTEAPWVV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | May act as an inducible transporter in the biliary and intestinal excretion of organic anions. Acts as an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. |
Sequence Annotation | DOMAIN 310 593 ABC transmembrane type-1 1.
DOMAIN 626 850 ABC transporter 1.
DOMAIN 967 1248 ABC transmembrane type-1 2.
DOMAIN 1287 1519 ABC transporter 2.
NP_BIND 660 667 ATP 1 (Potential).
NP_BIND 1319 1326 ATP 2 (Potential).
MOD_RES 903 903 Phosphoserine.
MOD_RES 923 923 Phosphoserine.
CARBOHYD 18 18 N-linked (GlcNAc...) (Potential).
CARBOHYD 1002 1002 N-linked (GlcNAc...) (Potential). |
Keyword | Alternative splicing; ATP-binding; Complete proteome; Glycoprotein; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1523 AA |
Protein Sequence | MDRLCGSGEL GSKFWDSNLS IYTNTPDLTP CFQNSLLAWV PCIYLWAALP CYLFYLRHHQ 60
LGYIVLSWLS RLKTALGVLL WCVSWVDLFY SFHGLIHGSS PAPVFFVTPL VVGITMLLAT 120
LLIQYERLRG VQSSGVLIIF WLLCVICAII PFRSKILSAL AEGKILDPFR FTTFYIYFAL 180
VFCALILSCF KEKPPLFSPE NLDTNPCPEA SAGFFSRLSF WWFTRLAILG YRRPLEDRDL 240
WSLSEEDCSH KVVQRLLEAW QKQQNQASGS QTATAEPKIP GEDAVLLKPR PKSKQPSFLR 300
ALVRTFTSSL LMSACFNLIQ NLLGFVNPQL LSILIRFISD PTAPTWWGFL LAGLMFLSST 360
MQTLILHQYY HCIFVMALRL RTAIIGVIYR KALVITNSVK RESTVGEMVN LMSVDAQRFM 420
DVSPFINLLW SAPLQVILAI YFLWQILGPS ALAGVAVIVL LIPLNGAVSM KMKTYQVKQM 480
KFKDSRIKLM SEILNGIKVL KLYAWEPSFL EQVKGIRQSE LQLLRKGAYL QAISTFIWIC 540
TPFLVTLITL GVYVYVDESN VLDAEKAFVS LSLFNILKIP LNMLPQLISG LTQASVSLKR 600
IQDFLNQNEL DPQCVERKTI SPGYAITIHN GTFTWAQDLP PTLHSLNIQI PKGALVAVVG 660
PVGCGKSSLV SALLGEMEKL EGVVSVKGSV AYVPQQAWIQ NCTLQENVLF GQPMNPKRYQ 720
QALETCALLA DLDVLPGGDQ TEIGEKGINL SGGQRQRVSL ARAVYSDANI FLLDDPLSAV 780
DSHVAKHIFD QVIGPEGVLA GKTRVLVTHG ISFLPQTDFI IVLAGGQVSE MGHYSALLQH 840
DGSFANFLRN YAPDEDQEDH EAALQNANEE VLLLEDTLST HTDLTDNEPA IYEVRKQFMR 900
EMSSLSSEGE VQNRTMPKKH TNSLEKEALV TKTKETGALI KEEIAETGNV KLSVYWDYAK 960
SMGLCTTLSI CLLYGGQSAA AIGANVWLSA WSNDAEEHGQ QNKTSVRLGV YAALGILQGL 1020
LVMLSAFTMV VGAIQAARLL HEALLHNKIR SPQSFFDTTP SGRILNRFSK DIYVIDEVLA 1080
PTILMLLNSF FTSISTIMVI VASTPLFMVV VLPLAVLYGF VQRFYVATSR QLKRLESISR 1140
SPIFSHFSET VTGTSVIRAY GRIQDFKVLS DTKVDNNQKS SYPYIASNRW LGVHVEFVGN 1200
CVVLFAALFA VIGRNSLNPG LVGLSVSYAL QVTMALNWMI RMISDLESNI IAVERVKEYS 1260
KTKTEAPWVV ESNRAPEGWP TRGMVEFRNY SVRYRPGLEL VLKNVTVHVQ GGEKVGIVGR 1320
TGAGKSSMTL CLFRILEAAE GEIVIDGLNV AHIGLHDLRS QLTIIPQDPI LFSGTLRMNL 1380
DPFGRYSEED IWRALELSHL NTFVSSQPAG LDFQCAEGGD NLSVGQRQLV CLARALLRKS 1440
RVLVLDEATA AIDLETDDLI QGTIRTQFED CTVLTIAHRL NTIMDYNRVL VLDKGVVAEF 1500
DSPVNLIAAG GIFYGMAKDA GLA 1523 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IDA:MGI. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IEA:InterPro. GO:0006200; P:ATP catabolic process; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |