UniProt Accession

 PTPRA_MOUSE; P18052; A2AHF2; Q61808 

Genbank Protein ID

 M36033; M36034; L13607; AL731707; CH466519; Z23054; Z23055 

Genbank Nucleotide ID

 AAA39448.1; AAA39449.2; CAM13265.1; EDL28272.1; CAA80589.1; CAA80590.1 

Protein Name

 Receptor-type tyrosine-protein phosphatase alpha 

Protein Synonyms/Alias

 Protein-tyrosine phosphatase alpha; R-PTP-alpha; LCA-related phosphatase; PTPTY-28 

Gene Name

 Ptpra 

Gene Synonyms/Alias

 Lrp; Ptpa 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
279	AVSKDAVKALNKTTP	acetylation	[1]
334	FINGYQEKNKFIAAQ	ubiquitination	[2]
409	LVDYTVRKFCIQQVG	acetylation	[3]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

  

Sequence Annotation

 DOMAIN 232 528 Tyrosine-protein phosphatase 1.
 DOMAIN 560 818 Tyrosine-protein phosphatase 2.
 REGION 469 475 Substrate binding (By similarity).
 ACT_SITE 469 469 Phosphocysteine intermediate (By
 ACT_SITE 759 759 Phosphocysteine intermediate (By
 BINDING 437 437 Substrate (By similarity).
 BINDING 513 513 Substrate (By similarity).
 MOD_RES 180 180 Phosphoserine.
 MOD_RES 204 204 Phosphoserine.
 MOD_RES 825 825 Phosphotyrosine.
 CARBOHYD 21 21 N-linked (GlcNAc...) (Potential).
 CARBOHYD 47 47 N-linked (GlcNAc...) (Potential).
 CARBOHYD 51 51 N-linked (GlcNAc...) (Potential).
 CARBOHYD 68 68 N-linked (GlcNAc...) (Potential).
 CARBOHYD 80 80 N-linked (GlcNAc...) (Potential).
 CARBOHYD 86 86 N-linked (GlcNAc...) (Potential).
 CARBOHYD 104 104 N-linked (GlcNAc...) (Potential).
 CARBOHYD 124 124 N-linked (GlcNAc...) (Potential).  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Direct protein sequencing; Glycoprotein; Hydrolase; Membrane; Phosphoprotein; Protein phosphatase; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 829 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
 GO:0008286; P:insulin receptor signaling pathway; IMP:MGI.
 GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
 GO:0006468; P:protein phosphorylation; IDA:MGI. 

Interpro

 IPR000387; Tyr/Dual-sp_Pase.
 IPR016130; Tyr_Pase_AS.
 IPR000242; Tyr_Pase_rcpt/non-rcpt.
 IPR016336; Tyr_Pase_rcpt_a/e-type.
 IPR027262; Tyr_Pase_rcpt_alpha. 

Pfam

 PF00102; Y_phosphatase 

SMART

 SM00194; PTPc 

PROSITE

 PS00383; TYR_PHOSPHATASE_1
 PS50056; TYR_PHOSPHATASE_2
 PS50055; TYR_PHOSPHATASE_PTP 

PRINTS

 PR00700; PRTYPHPHTASE.