CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022576
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein NYNRIN 
Protein Synonyms/Alias
 NYN domain and retroviral integrase catalytic domain-containing protein; Protein cousin of GIN1 
Gene Name
 NYNRIN 
Gene Synonyms/Alias
 CGIN1; KIAA1305 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
321NHTQALLKQRQVQKIubiquitination[1]
641KTSPAGPKTPKAQAGubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
 DOMAIN 1609 1774 Integrase catalytic.
 MOD_RES 863 863 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Complete proteome; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1898 AA 
Protein Sequence
MLLSGGDPPA QEWFMVQTKS KPRVQRQRLQ VQRIFRVKLN AFQSRPDTPY FWLQLEGPRE 60
NMGKAKEYLK GLCSPELWKE VRYPPILHCA FLGAQGLFLD CLCWSTLAYL VPGPPGSLMV 120
GGLTESFIMT QNWLEELVGR LRWGPAPLLT PRGIWEAEVT RAFGALVWIR GDQHAGDLLQ 180
LPPAVQELLL SLVRDAAGKE DIIEWLSRFG ISDSHSDPEV LICPPQQQKE APAMVSVGES 240
PGPFVDMGTL QNRGPENSKR LSSLGATGSL ITAQSTPQEA ANQLVRVGSN NQDGMDSAQE 300
EGTVQATSSQ DSTNHTQALL KQRQVQKIED KLLFQPPVSA LGVCPPWKAW TPGPAFGPLW 360
PGAIAATFWR INELHSLHLA WLLSQACFNF PFWQRPLGPI QLKLPGQNPL PLNLEWKQKE 420
LAPLPSAESP AGRPDGGLGG EAALQNCPRP EISPKVTSLL VVPGSSDVKD KVSSDLPQIG 480
PPLTSTPQLQ AGGEPGDQGS MQLDFKGLEE GPAPVLPTGQ GKPVAQGGLT DQSVPGAQTV 540
PETLKVPMAA AVPKAENPSR TQVPSAAPKL PTSRMMLAVH TEPAAPEVPL APTKPTAQLM 600
ATAQKTVVNQ PVLVAQVEPT TPKTPQAQKM PVAKTSPAGP KTPKAQAGPA ATVSKAPAAS 660
KAPAAPKVPV TPRVSRAPKT PAAQKVPTDA GPTLDVARLL SEVQPTSRAS VSLLKGQGQA 720
GRQGPQSSGT LALSSKHQFQ MEGLLGAWEG APRQPPRHLQ ANSTVTSFQR YHEALNTPFE 780
LNLSGEPGNQ GLRRVVIDGS SVAMVHGLQH FFSCRGIAMA VQFFWNRGHR EVTVFVPTWQ 840
LKKNRRVRES HFLTKLHSLK MLSITPSQLE NGKKITTYDY RFMVKLAEET DGIIVTNEQI 900
HILMNSSKKL MVKDRLLPFT FAGNLFMVPD DPLGRDGPTL DEFLKKPNRL DTDIGNFLKV 960
WKTLPPSSAS VTELSDDADS GPLESLPNME EVREEKEERQ DEEQRQGQGT QKAAEEDDLD 1020
SSLASVFRVE CPSLSEEILR CLSLHDPPDG ALDIDLLPGA ASPYLGIPWD GKAPCQQVLA 1080
HLAQLTIPSN FTALSFFMGF MDSHRDAIPD YEALVGPLHS LLKQKPDWQW DQEHEEAFLA 1140
LKRALVSALC LMAPNSQLPF RLEVTVSHVA LTAILHQEHS GRKHPIAYTS KPLLPDEESQ 1200
GPQSGGDSPY AVAWALKHFS RCIGDTPVVL DLSYASRTTA DPEVREGRRV SKAWLIRWSL 1260
LVQDKGKRAL ELALLQGLLG ENRLLTPAAS MPRFFQVLPP FSDLSTFVCI HMSGYCFYRE 1320
DEWCAGFGLY VLSPTSPPVS LSFSCSPYTP TYAHLAAVAC GLERFGQSPL PVVFLTHCNW 1380
IFSLLWELLP LWRARGFLSS DGAPLPHPSL LSYIISLTSG LSSLPFIYRT SYRGSLFAVT 1440
VDTLAKQGAQ GGGQWWSLPK DVPAPTVSPH AMGKRPNLLA LQLSDSTLAD IIARLQAGQK 1500
LSGSSPFSSA FNSLSLDKES GLLMFKGDKK PRVWVVPTQL RRDLIFSVHD IPLGAHQRPE 1560
ETYKKLRLLG WWPGMQEHVK DYCRSCLFCI PRNLIGSELK VIESPWPLRS TAPWSNLQIE 1620
VVGPVTISEE GHKHVLIVAD PNTRWVEAFP LKPYTHTAVA QVLLQHVFAR WGVPVRLEAA 1680
QGPQFARHVL VSCGLALGAQ VASLSRDLQF PCLTSSGAYW EFKRALKEFI FLHGKKWAAS 1740
LPLLHLAFRA SSTDATPFKV LTGGESRLTE PLWWEMSSAN IEGLKMDVFL LQLVGELLEL 1800
HWRVADKASE KAENRRFKRE SQEKEWNVGD QVLLLSLPRN GSSAKWVGPF YIGDRLSLSL 1860
YRIWGFPTPE KLGCIYPSSL MKAFAKSGTP LSFKVLEQ 1898 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0015074; P:DNA integration; IEA:InterPro. 
Interpro
 IPR001584; Integrase_cat-core.
 IPR021869; RNase_Zc3h12.
 IPR012337; RNaseH-like_dom. 
Pfam
 PF11977; RNase_Zc3h12a 
SMART
  
PROSITE
 PS50994; INTEGRASE 
PRINTS