CPLM-010970

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-010970

UniProt Accession

CACB1_HUMAN; Q02641; A8K114; O15331; Q02639; Q02640; Q8N3X9; Q9C085; Q9UD79

Genbank Protein ID

M92303; M92301; M92302; M76560; L06110; L06111; L06112; AB054985; U86960; U86952; U86953; U86954; U86955; U86956; U86957; U86958; U86959; U86960; U86952; U86953; U86954; U86955; U86956; U86957; U86958; U86959; U86961; U86952; U86953; U86954; U86955; U86956; U86957; U86958; U86959; U86960; AK289729; CH471152; BC037311; Z21725; Z21726

Genbank Nucleotide ID

AAA35633.1; AAA35631.1; AAA35632.1; AAA51894.1; AAA36167.1; AAA36168.1; AAA36169.1; BAB21444.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58779.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58780.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; AAB58781.1; BAF82418.1; EAW60562.1; AAH37311.2; CAA79824.1; CAA79825.1

Protein Name

Voltage-dependent L-type calcium channel subunit beta-1

Protein Synonyms/Alias

CAB1; Calcium channel voltage-dependent subunit beta 1

Gene Name

CACNB1

Gene Synonyms/Alias

CACNLB1

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
261	KRIPFFKKTEHVPPY	ubiquitination	[1]

Reference

[1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]

Functional Description

The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.

Sequence Annotation

DOMAIN 100 161 SH3.
MOD_RES 186 186 Phosphoserine (By similarity).
MOD_RES 499 499 Phosphothreonine (By similarity).

Keyword

Alternative splicing; Calcium; Calcium channel; Calcium transport; Cell membrane; Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Polymorphism; Reference proteome; SH3 domain; Transport; Voltage-gated channel.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

598 AA

Protein Sequence

MVQKTSMSRG PYPPSQEIPM EVFDPSPQGK YSKRKGRFKR SDGSTSSDTT SNSFVRQGSA 60
ESYTSRPSDS DVSLEEDREA LRKEAERQAL AQLEKAKTKP VAFAVRTNVG YNPSPGDEVP 120
VQGVAITFEP KDFLHIKEKY NNDWWIGRLV KEGCEVGFIP SPVKLDSLRL LQEQKLRQNR 180
LGSSKSGDNS SSSLGDVVTG TRRPTPPASG NEMTNLAFEL DPLELEEEEA ELGEQSGSAK 240
TSVSSVTTPP PHGKRIPFFK KTEHVPPYDV VPSMRPIILV GPSLKGYEVT DMMQKALFDF 300
LKHRFDGRIS ITRVTADISL AKRSVLNNPS KHIIIERSNT RSSLAEVQSE IERIFELART 360
LQLVALDADT INHPAQLSKT SLAPIIVYIK ITSPKVLQRL IKSRGKSQSK HLNVQIAASE 420
KLAQCPPEMF DIILDENQLE DACEHLAEYL EAYWKATHPP SSTPPNPLLN RTMATAALAA 480
SPAPVSNLQV QVLTSLRRNL GFWGGLESSQ RGSVVPQEQE HAM 523

Gene Ontology

GO:0016529; C:sarcoplasmic reticulum; IEA:Compara.
GO:0030315; C:T-tubule; IEA:Compara.
GO:0005891; C:voltage-gated calcium channel complex; TAS:ProtInc.
GO:0008331; F:high voltage-gated calcium channel activity; IEA:Compara.
GO:0005245; F:voltage-gated calcium channel activity; TAS:ProtInc.
GO:0007411; P:axon guidance; TAS:Reactome.
GO:0006612; P:protein targeting to membrane; IEA:Compara.

Interpro

IPR008144; Guanylate_kin.
IPR008145; Guanylate_kin/L-typ_Ca_channel.
IPR027417; P-loop_NTPase.
IPR001452; SH3_domain.
IPR005443; VDCC_L_b1su.
IPR000584; VDCC_L_bsu.

Pfam

PF00625; Guanylate_kin
PF12052; VGCC_beta4Aa_N

SMART

SM00072; GuKc
SM00326; SH3

PROSITE

PS50002; SH3

PRINTS

PR01626; LCACHANNELB.
PR01627; LCACHANNELB1.