CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015568
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ubinuclein-2 
Protein Synonyms/Alias
  
Gene Name
 UBN2 
Gene Synonyms/Alias
 KIAA2030 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
458GLPVLLEKRIEDLRVubiquitination[1]
468EDLRVAAKLFDEEGRubiquitination[1]
544REPLQKLKLAVSNVMubiquitination[1]
630CYELEPNKSQSAEDYubiquitination[1]
976SLIKTSDKPLMYRLPacetylation[2, 3]
1148KNLQAPSKLTNSSSTacetylation[2, 3, 4, 5]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [5] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
 MOD_RES 13 13 Phosphoserine.
 MOD_RES 250 250 Phosphoserine.
 MOD_RES 584 584 Phosphoserine.
 MOD_RES 1148 1148 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1347 AA 
Protein Sequence
MAEPRRVAFI SLSPVRRREA EYPGPEREPE YPREPPRLEP QPYREPARAE PPAPREPAPR 60
SDAQPPSREK PLPQREVSRA EPPMSLQREP PRPEPPPPFP PLPLQPPPPR ESASRAEQPP 120
RPPRETVRLE LVLKDPTDES CVEFSYPELL LCGEQRKKLI HTEDPFNDEH QERQEVEMLA 180
KKFEMKYGGK PRKHRKDRLQ DLIDIGFGYD ETDPFIDNSE AYDELVPASL TTKYGGFYIN 240
TGTLQFRQAS DTEEDDITDN QKHKPPKVPK IKEDDIEMKK RKRKEEGEKE KKPRKKVPKQ 300
LGVVALNSHK SEKKKKRYKD SLSLAAMIRK FQKEKDALKK ESNPKVPVTL STPSLNKPPC 360
AAAALGNDVP DLNLSSGDPD LPIFVSTNEH ELFQEAENAL EMLDDFDFDR LLDAASDGSP 420
LSESGGENGT TTQPTYTSQV MPKVVPTLPE GLPVLLEKRI EDLRVAAKLF DEEGRKKFFT 480
QDMNNILLDI ELQLQELGPV IRSGVYSHLE AFVPCNKETL VKRLKKLHLN VQDDRLREPL 540
QKLKLAVSNV MPEQLFKYQE DCQARSQAKC AKLQTDEERE KNGSEEDDDE KPGKRVIGPR 600
KKFHWDDTIR TLLCNLVEIK LGCYELEPNK SQSAEDYLKS FMETEVKPLW PKGWMQARML 660
FKESRSVHNH LTSAPAKKKV IPAPKPKVKE VMVKTLPLHS FPTMLKECSP KKDQKTPTSL 720
VASVSGPPTS SSTAAIAAAS SSSAPAQETI CLDDSLDEDL SFHSPSLDLV SEALAVINNG 780
NKGPPVGSRI SMPTTKPRPG LREEKLASIM SKLPLATPKK LDSTQTTHSS SLIAGHTGPV 840
PKKPQDLAHT GISSGLIAGS SIQNPKVSLE PLPARLLQQG LQRSSQIHTS SSSQTHVSSS 900
SQAQIAASSH ALGTSEAQDA SSLTQVTKVH QHSAVQQNYV SPLQATISKS QTNPVVKLSN 960
NPQLSCSSSL IKTSDKPLMY RLPLSTPSPG NGSQGSHPLV SRTVPSTTTS SNYLAKAMVS 1020
QISTQGFKSP FSMAASPKLA ASPKPATSPK PLPSPKPSAS PKPSLSAKPS VSTKLISKSN 1080
PTPKPTVSPS SSSPNALVAQ GSHSSTNSPV HKQPSGMNIS RQSPTLNLLP SSRTSGLPPT 1140
KNLQAPSKLT NSSSTGTVGK NSLSGIAMNV PASRGSNLNS SGANRTSLSG GTGSGTQGAT 1200
KPLSTPHRPS TASGSSVVTA SVQSTAGASL LANASPLTLM TSPLSVTNQN VTPFGMLGGL 1260
VPVTMPFQFP LEIFGFGTDT AGVTTTSGST SAAFHHSLTQ NLLKGLQPGG AQHAATLSHS 1320
PLPAHLQQAF HDGGQSKGDT KLPRKSQ 1347 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR014840; HRD.
 IPR026943; Ubinuclein-2.
 IPR026949; Ubinuclein/Yemanuclein.
 IPR026947; UBN_middle_dom. 
Pfam
 PF08729; HRD
 PF14075; UBN_AB 
SMART
  
PROSITE
  
PRINTS