CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010388
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Thymidylate synthase 
Protein Synonyms/Alias
 TS; TSase 
Gene Name
 thyA 
Gene Synonyms/Alias
 MPN_320; MP516 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
76IKYLVDNKVNIWNEWacetylation[1]
100HFNGESQKEFIERIRacetylation[1]
111ERIRQDAKFAQQFGNacetylation[1]
125NLGPVYGKQWRDFNGacetylation[1]
137FNGVDQLKKVIAQIKacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819] 
Functional Description
 Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity). 
Sequence Annotation
 ACT_SITE 170 170 By similarity.  
Keyword
 Complete proteome; Cytoplasm; Methyltransferase; Nucleotide biosynthesis; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 287 AA 
Protein Sequence
MQQYLDLARY VLEHGKYRPN RTDTAGIGVF GYQMHFDISK HFPLLTTKKV HWKSIVHELL 60
WFIKGDTNIK YLVDNKVNIW NEWPYESFKK SPHFNGESQK EFIERIRQDA KFAQQFGNLG 120
PVYGKQWRDF NGVDQLKKVI AQIKVNPFSR RLIVSSWNPN EVDQMLLPPC HSLYQFYVQD 180
GQLSCQLYQR SGDIFLGIPF NIASYSLLVY LVAKETNLKP GSFVHTIGDA HIYENHLEQI 240
KLQLTRQPKP LPKVVLKSDK SIFDYQFDDI ELVDYDHHPT IKGEVAV 287 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0004799; F:thymidylate synthase activity; IEA:HAMAP.
 GO:0006231; P:dTMP biosynthetic process; IEA:HAMAP.
 GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway. 
Interpro
 IPR023451; Thymidate_synth/dCMP_Mease.
 IPR000398; Thymidylate_synthase.
 IPR020940; Thymidylate_synthase_AS. 
Pfam
 PF00303; Thymidylat_synt 
SMART
  
PROSITE
 PS00091; THYMIDYLATE_SYNTHASE 
PRINTS
 PR00108; THYMDSNTHASE.