CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006867
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Nucleoporin NUP170 
Protein Synonyms/Alias
 Nuclear pore protein NUP170 
Gene Name
 NUP170 
Gene Synonyms/Alias
 NLE3; YBL079W; YBL0725 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
106KPLDLAGKYIDHLQHacetylation[1]
548QTHQQEKKENSSVTGubiquitination[2]
563TTATAGSKTVKQQPVubiquitination[2]
1252SVSPLSQKQRIVQLAubiquitination[2]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919]
 [2] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. NUP170 probably plays an important role in NPC assembly and organization. In addition it is required for chromosome transmission fidelity. 
Sequence Annotation
 REGION 233 261 Leucine-zipper (Potential).
 MOD_RES 1247 1247 Phosphoserine.  
Keyword
 3D-structure; Complete proteome; Direct protein sequencing; Membrane; mRNA transport; Nuclear pore complex; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Translocation; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1502 AA 
Protein Sequence
MFQSFFHNNG PAAAGETFSD SRSYPLTNHQ EVPRNGLNEL ASSATKAQQQ PTHILNSYPI 60
TGSNPLMRAS AMGATSGSIN PNMSNMNEHI RVSGMGTSKP LDLAGKYIDH LQHKDSNTPV 120
LDERSYYNSG VDYNFSREKN GLGAFTPFEK QDVFNIPDEI LHEFSTSQTK TDMGIFPELN 180
RCWITIDNKL ILWNINNDNE YQVVDDMKHT IQKVALVRPK PNTFVPAVKH LLLISTTMEL 240
FMFAISLDKA TNELSVFNTH LSVPVQGIDV IDIVSHERSG RIFFAGQASG LNIWELHYSG 300
SDDWFNSKCS KVCLTKSALL SLLPTNMLSQ IPGVDFIQAL FEDNSNGNGG FSQETITQLT 360
IDQQRGIIYS LSSKSTIRAY VITEKSLEGP MSIEPAYISR IIGTTTARAA PILGPKYLKI 420
VKISSVAPEE NNNLFLVALT VGGVRLYFNG SMGRFNIEAL RLESIKFPPS SVTPEVIQQE 480
LLHQQQEQAK RSFPFFSNLM SSEPVLLKFQ KKSSVLLETT KASTIISPGI FFSAVIKSSQ 540
QTHQQEKKEN SSVTGTTATA GSKTVKQQPV TLQHKLFVSV PDYGILKTHG KYVENATFLE 600
TAGPVQQIIP LSGLFNATTK PQGFANEFAT QYTSETLRVA VLTSTSIEIY KYRTPDEIFE 660
DLIDNPLPFV LNYGAAEACS TALFVTCKSN KSEKLRSNAL TFLTMGIPGV VDIKPVYNRY 720
SVSTVSSLLS KPTLSTATTN LQQSITGFSK PSPANKEDFD LDDVILSPRF YGIALLITRL 780
LRDIWGRHVF MTFTDNRVTS HAFISSSDPI TPSINNLKSD EISQNRNIIS KVSISKDCIE 840
YYLSSINILN EFFITYGDSI SQISAPYVLA NNSNGRVIDK TEEVANQAES IAINAMIKMV 900
QSIKEGLSFL NVLYEESEVE GFDNQYLGFK DIISFVSLDV QKDLVKLDFK DLFAPNDKTK 960
SLIREILLSI INRNITKGAS IEYTATALQE RCGSFCSASD ILGFRAIEHL RRAKEIGLRN 1020
YDSLNYHLKN ATALLEQIVD DLSIEKLKEA VSMMLSVNYY PKSIEFLLNI ANSMDKGKLA 1080
CQYVANGFLE NDDRKQYYDK RILVYDLVFD TLIKVDELAE KKQSSKTQNQ ISISNDDEVK 1140
LRQKSYEAAL KYNDRLFHYH MYDWLVSQNR EEKLLDIETP FILPYLMEKA GSSLKISNIL 1200
WVYYSRRSKF FESAEILYRL ATSNFDITLF ERIEFLSRAN GFCNSVSPLS QKQRIVQLAS 1260
RIQDACEVAG IQGDILSLVY TDARIDSAIK DELIKTLDGK ILSTSELFND FAVPLSYHEI 1320
ALFIFKIADF RDHEVIMAKW DELFQSLRME FNNTGKKEDS MNFINLLSNV LIKIGKNVQD 1380
SEFIFPIFEL FPIVCNFFYE TLPKEHIVSG SIVSIFITAG VSFNKMYYIL KELIETSDSD 1440
NSVFNKEMTW LIHEWYKSDR KFRDIISYND IIHLKEYKID NDPIEKYVKN SGNNLGICFY 1500
KE 1502 
Gene Ontology
 GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
 GO:0044611; C:nuclear pore inner ring; IDA:SGD.
 GO:0017056; F:structural constituent of nuclear pore; IMP:SGD.
 GO:0007059; P:chromosome segregation; IMP:SGD.
 GO:0007094; P:mitotic spindle assembly checkpoint; IMP:SGD.
 GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
 GO:0051292; P:nuclear pore complex assembly; IGI:SGD.
 GO:0006913; P:nucleocytoplasmic transport; IC:SGD.
 GO:0036228; P:protein targeting to nuclear inner membrane; IMP:SGD. 
Interpro
 IPR007187; Nucleoporin_Nup133/Nup155_C.
 IPR014908; Nucleoporin_Nup133/Nup155_N.
 IPR004870; Nucleoporin_Nup155. 
Pfam
 PF03177; Nucleoporin_C
 PF08801; Nucleoporin_N 
SMART
  
PROSITE
  
PRINTS