| Tag | Content |
|---|
| CPLM ID | CPLM-004273 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein translocation protein SEC63 |
Protein Synonyms/Alias | Protein NPL1; Sec62/63 complex 73 kDa subunit |
Gene Name | SEC63 |
Gene Synonyms/Alias | NPL1; PTL1; YOR254C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 385 | DKEHFITKTGDIHTL | acetylation | [1] | | 534 | QTPIIIEKLSYKNLN | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Acts as component of the Sec62/63 complex which is involved in SRP-independent post-translational translocation across the endoplasmic reticulum (ER) and functions together with the Sec61 complex and KAR2 in a channel-forming translocon complex. A cycle of assembly and disassembly of Sec62/63 complex from SEC61 may govern the activity of the translocon. SEC63 may affect SEC1-polypeptide interactions by increasing the affinity of targeting pathways for SEC61 and/or by modifying SEC61 to allow more efficient polypeptide interaction. May also be involved in SRP-dependent cotranslational translocation. Is essential for cell growth and for germination. |
Sequence Annotation | DOMAIN 123 198 J.
DOMAIN 228 532 SEC63.
REPEAT 461 471 1.
REPEAT 493 503 2.
REGION 461 503 2 X 11 AA repeats.
MOD_RES 512 512 Phosphoserine. |
Keyword | Chaperone; Complete proteome; Endoplasmic reticulum; Membrane; Nucleus; Phosphoprotein; Protein transport; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 663 AA |
Protein Sequence | MPTNYEYDEA SETWPSFILT GLLMVVGPMT LLQIYQIFFG ANAEDGNSGK SKEFNEEVFK 60
NLNEEYTSDE IKQFRRKFDK NSNKKSKIWS RRNIIIIVGW ILVAILLQRI NSNDAIKDAA 120
TKLFDPYEIL GISTSASDRD IKSAYRKLSV KFHPDKLAKG LTPDEKSVME ETYVQITKAY 180
ESLTDELVRQ NYLKYGHPDG PQSTSHGIAL PRFLVDGSAS PLLVVCYVAL LGLILPYFVS 240
RWWARTQSYT KKGIHNVTAS NFVSNLVNYK PSEIVTTDLI LHWLSFAHEF KQFFPDLQPT 300
DFEKLLQDHI NRRDSGKLNN AKFRIVAKCH SLLHGLLDIA CGFRNLDIAL GAINTFKCIV 360
QAVPLTPNCQ ILQLPNVDKE HFITKTGDIH TLGKLFTLED AKIGEVLGIK DQAKLNETLR 420
VASHIPNLKI IKADFLVPGE NQVTPSSTPY ISLKVLVRSA KQPLIPTSLI PEENLTEPQD 480
FESQRDPFAM MSKQPLVPYS FAPFFPTKRR GSWCCLVSSQ KDGKILQTPI IIEKLSYKNL 540
NDDKDFFDKR IKMDLTKHEK FDINDWEIGT IKIPLGQPAP ETVGDFFFRV IVKSTDYFTT 600
DLDITMNMKV RDSPAVEQVE VYSEEDDEYS TDDDETESDD ESDASDYTDI DTDTEAEDDE 660
SPE 663 |
Gene Ontology | GO:0016021; C:integral to membrane; ISM:SGD. GO:0005739; C:mitochondrion; IDA:SGD. GO:0005637; C:nuclear inner membrane; IEA:UniProtKB-SubCell. GO:0031207; C:Sec62/Sec63 complex; IPI:SGD. GO:0008565; F:protein transporter activity; IMP:SGD. GO:0046967; P:cytosol to ER transport; IMP:SGD. GO:0031204; P:posttranslational protein targeting to membrane, translocation; IDA:SGD. GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |