UniProt Accession

 GSTP1_RAT; P04906 

Genbank Protein ID

 X02904; L29427; BC058439; BC058440 

Genbank Nucleotide ID

 CAA26664.1; AAB59718.1; AAH58439.1; AAH58440.1 

Protein Name

 Glutathione S-transferase P 

Protein Synonyms/Alias

 Chain 7; GST 7-7; GST class-pi 

Gene Name

 Gstp1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
82	RSLGLYGKDQKEAAL	acetylation	[1]
85	GLYGKDQKEAALVDM	acetylation	[1]
128	KALPGHLKPFETLLS	acetylation	[1]
191	LSARPKIKAFLSSPD	acetylation	[1]
209	RPINGNGKQ******	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration (By similarity). 

Sequence Annotation

 DOMAIN 2 81 GST N-terminal.
 DOMAIN 83 204 GST C-terminal.
 REGION 52 53 Glutathione binding (By similarity).
 REGION 65 66 Glutathione binding (By similarity).
 BINDING 8 8 Glutathione (By similarity).
 BINDING 14 14 Glutathione (By similarity).
 BINDING 39 39 Glutathione (By similarity).
 BINDING 45 45 Glutathione (By similarity).
 MOD_RES 4 4 Phosphotyrosine; by EGFR (By similarity).
 MOD_RES 109 109 Phosphotyrosine (By similarity).
 MOD_RES 128 128 N6-acetyllysine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Mitochondrion; Nucleus; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:RGD.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0043234; C:protein complex; ISS:BHF-UCL.
 GO:0008144; F:drug binding; IDA:RGD.
 GO:0043295; F:glutathione binding; IDA:RGD.
 GO:0004364; F:glutathione transferase activity; IDA:RGD.
 GO:0008432; F:JUN kinase binding; ISS:BHF-UCL.
 GO:0019207; F:kinase regulator activity; ISS:BHF-UCL.
 GO:0071460; P:cellular response to cell-matrix adhesion; IEP:RGD.
 GO:0071364; P:cellular response to epidermal growth factor stimulus; IEP:RGD.
 GO:0071385; P:cellular response to glucocorticoid stimulus; IEP:RGD.
 GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; ISS:BHF-UCL.
 GO:0035726; P:common myeloid progenitor cell proliferation; ISS:BHF-UCL.
 GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:BHF-UCL.
 GO:0048147; P:negative regulation of fibroblast proliferation; ISS:BHF-UCL.
 GO:0043124; P:negative regulation of I-kappaB kinase/NF-kappaB cascade; ISS:BHF-UCL.
 GO:0032691; P:negative regulation of interleukin-1 beta production; ISS:BHF-UCL.
 GO:0043508; P:negative regulation of JUN kinase activity; ISS:BHF-UCL.
 GO:0070664; P:negative regulation of leukocyte proliferation; ISS:BHF-UCL.
 GO:0071638; P:negative regulation of monocyte chemotactic protein-1 production; ISS:BHF-UCL.
 GO:0060547; P:negative regulation of necrotic cell death; ISS:BHF-UCL.
 GO:0051771; P:negative regulation of nitric-oxide synthase biosynthetic process; ISS:BHF-UCL.
 GO:0032873; P:negative regulation of stress-activated MAPK cascade; ISS:BHF-UCL.
 GO:0032720; P:negative regulation of tumor necrosis factor production; ISS:BHF-UCL.
 GO:0014003; P:oligodendrocyte development; IEP:RGD.
 GO:0031100; P:organ regeneration; IEP:RGD.
 GO:0032930; P:positive regulation of superoxide anion generation; ISS:BHF-UCL.
 GO:0043200; P:response to amino acid stimulus; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
 GO:0046689; P:response to mercury ion; IEP:RGD.
 GO:0000302; P:response to reactive oxygen species; ISS:BHF-UCL.
 GO:0009636; P:response to toxic substance; IEP:RGD.
 GO:0006805; P:xenobiotic metabolic process; IDA:RGD. 

Interpro

 IPR010987; Glutathione-S-Trfase_C-like.
 IPR004045; Glutathione_S-Trfase_N.
 IPR017933; Glutathione_S_Trfase/Cl_chnl_C.
 IPR004046; GST_C.
 IPR003082; GST_pi.
 IPR012336; Thioredoxin-like_fold. 

Pfam

 PF00043; GST_C
 PF02798; GST_N 

SMART

  

PROSITE

 PS50405; GST_CTER
 PS50404; GST_NTER 

PRINTS

 PR01268; GSTRNSFRASEP.