| Tag | Content |
|---|
| CPLM ID | CPLM-012895 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Far upstream element-binding protein 1 |
Protein Synonyms/Alias | FBP; FUSE-binding protein 1 |
Gene Name | Fubp1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 28 | GGVNDAFKDALQRAR | acetylation | [1] | | 40 | RARQIAAKIGGDAGT | acetylation | [1] | | 60 | DYGYGGQKRPLEDGD | acetylation | [1] | | 72 | DGDQPDAKKVPPQND | acetylation | [1] | | 228 | PQNTGADKPLRITGD | acetylation | [1] | | 238 | RITGDPYKVQQAKEM | acetylation | [1] | | 243 | PYKVQQAKEMVLELI | acetylation | [1] | | 307 | AGVRIQFKPDDGTTP | acetylation | [1] | | 395 | GKGGETIKSISQQSG | acetylation | [1] | | 420 | PNADPNMKLFTIRGT | acetylation | [1] |
|
Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription (By similarity). |
Sequence Annotation | DOMAIN 95 159 KH 1.
DOMAIN 180 246 KH 2.
DOMAIN 270 334 KH 3.
DOMAIN 371 438 KH 4.
MOD_RES 2 2 N-acetylalanine (By similarity).
MOD_RES 135 135 Phosphoserine (By similarity).
MOD_RES 148 148 Phosphothreonine (By similarity).
MOD_RES 625 625 Phosphoserine (By similarity). |
Keyword | Acetylation; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 639 AA |
Protein Sequence | MADYSTVPPP SSGSAGGGGG GGVNDAFKDA LQRARQIAAK IGGDAGTSLN SNDYGYGGQK 60
RPLEDGDQPD AKKVPPQNDS FGAQLPPMHQ QQRSVMTEEY KVPDGMVGFI IGRGGEQISR 120
IQQESGCKIQ IAPDSGGLPE RSCMLTGTPE SVQSAKRLLD QIVEKGRPAP GFHHGDGPGN 180
AVQEIMIPAS KAGLVIGKGG ETIKQLQERA GVKMVMIQDG PQNTGADKPL RITGDPYKVQ 240
QAKEMVLELI RDQGGFREVR NEYGSRIGGN EGIDVPIPRF AVGIVIGRNG EMIKKIQNDA 300
GVRIQFKPDD GTTPDRIAQI TGPPDRCQHA AEIITDLLRS VQAGNPGGPG PGGRGRGRGQ 360
GNWNMGPPGG LQEFNFIVPT GKTGLIIGKG GETIKSISQQ SGARIELQRN PPPNADPNMK 420
LFTIRGTPQQ IDYARQLIEE KIGGPVNPLG PPVPHGPHGV PGPHGPPGPP GPGTPMGPYN 480
PAPYNPGPPG PAPHGPPAPY APQGWGNAYP HWQQQAPPDP AKAGTDPNSA AWAAYYAHYY 540
QQQAQPPPAA PAGAPTTTQT NGQGDQQNPA PAGQVDYTKA WEEYYKKMGQ AVPAPAGAPP 600
GGQPDYSAAW AEYYRQQAAY YAQTSPQGMP QHPPAPQGQ 639 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0003723; F:RNA binding; IEA:InterPro. GO:0010628; P:positive regulation of gene expression; IEA:Compara. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |