CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037444
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 MCCC1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
248EAPAPGIKSEVRKKLacetylation[1]
471AALGLILKEKAMTDTubiquitination[2]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Biotin; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 598 AA 
Protein Sequence
MAAASAVSVL LVAAERNRWH RLPSLLLPPR TWVWRQRTMK YTTATDEAYS IGPAPSQQSY 60
LSMEKIIQVA KTSAAQAIHP GCGFLSENME FAELCKQEGI IFIGPPPSAI RDMGIKSTSK 120
SIMAAAGVPV VEGYHGEDQS DQCLKEHARR IGYPVMIKAV RGGGGKGMRI VRSEQEFQEQ 180
LESARREAKK SFNDDAMLIE KFVDTPRHVE VQVFGDHHGN AVYLFERDCS VQRRHQKIIE 240
EAPAPGIKSE VRKKLGEAAV RAAKAVNYVG AGTVEFIMDS KHNFCFMEMN TRLQVEHPVT 300
EMITGTDLVE WQLRIAAGEK IPLSQEEITL QGHAFEARIY AEDPSNNFMP VAGPLVHLST 360
PRADPSTRIE TGVRQGDEVS VHYDPMIAKL VVWAADRQAA LTKLRYSLRQ YNIVGLHTNI 420
DFLLNLSGHP EFEAGNVHTD FIPQHHKQLL LSRKAAAKES LCQAALGLIL KEKAMTDTFT 480
LQAHDQFSPF SSSSGRRLNI SYTRNMTLKD GKNNVAIAVT YNHDGSYSMQ IEDKTFQVLG 540
NLYSEGDCTY LKCSVNGVAS KAKLIILENT IYLFSKEGSI EIDIPVPKYL SSVSSQET 598 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004075; F:biotin carboxylase activity; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:InterPro. 
Interpro
 IPR011761; ATP-grasp.
 IPR013815; ATP_grasp_subdomain_1.
 IPR013816; ATP_grasp_subdomain_2.
 IPR011764; Biotin_carboxylation_dom.
 IPR005482; Biotin_COase_C.
 IPR005481; CarbamoylP_synth_lsu_N.
 IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
 IPR016185; PreATP-grasp_dom.
 IPR011054; Rudment_hybrid_motif. 
Pfam
 PF02785; Biotin_carb_C
 PF00289; CPSase_L_chain
 PF02786; CPSase_L_D2 
SMART
 SM00878; Biotin_carb_C 
PROSITE
 PS50975; ATP_GRASP
 PS50979; BC
 PS00867; CPSASE_2 
PRINTS