CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000663
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 MutS protein homolog 5 
Protein Synonyms/Alias
 hMSH5 
Gene Name
 MSH5 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
105QSVVTSAKQDENMTRubiquitination[1]
116NMTRFLGKLASQEHRubiquitination[1]
205RALGGLLKFLGRRRIubiquitination[1]
230VPILGFKKFMLTHLVubiquitination[1]
266YKVASGLKEGLSLFGubiquitination[1]
424DPEIDEKKRRLMGLPubiquitination[1]
440FLTEVARKELENLDSubiquitination[1]
501HYRSARTKELDALLGubiquitination[1]
601STECGGDKGRVKVITubiquitination[1]
605GGDKGRVKVITGPNSubiquitination[1]
615TGPNSSGKSIYLKQVubiquitination[1]
789DKLVARGKEVSDLIRubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Involved in meiotic recombination. Facilitate crossovers between homologs during meiosis (By similarity). 
Sequence Annotation
 NP_BIND 592 599 ATP (Potential).  
Keyword
 Alternative splicing; ATP-binding; Complete proteome; DNA-binding; Meiosis; Nucleotide-binding; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 834 AA 
Protein Sequence
MASLGANPRR TPQGPRPGAA SSGFPSPAPV PGPREAEEEE VEEEEELAEI HLCVLWNSGY 60
LGIAYYDTSD STIHFMPDAP DHESLKLLQR VLDEINPQSV VTSAKQDENM TRFLGKLASQ 120
EHREPKRPEI IFLPSVDFGL EISKQRLLSG NYSFIPDAMT ATEKILFLSS IIPFDCLLTP 180
PGDLRFTPIP LLIPSQVRAL GGLLKFLGRR RIGVELEDYN VSVPILGFKK FMLTHLVNID 240
QDTYSVLQIF KSESHPSVYK VASGLKEGLS LFGILNRCHC KWGEKLLRLW FTRPTHDLGE 300
LSSRLDVIQF FLLPQNLDMA QMLHRLLGHI KNVPLILKRM KLSHTKVSDW QVLYKTVYSA 360
LGLRDACRSL PQSIQLFRDI AQEFSDDLHH IASLIGKVVD FEGSLAENRF TVLPNIDPEI 420
DEKKRRLMGL PSFLTEVARK ELENLDSRIP SCSVIYIPLI GFLLSIPRLP SMVEASDFEI 480
NGLDFMFLSE EKLHYRSART KELDALLGDL HCEIRDQETL LMYQLQCQVL ARAAVLTRVL 540
DLASRLDVLL ALASAARDYG YSRPRYSPQV LGVRIQNGRH PLMELCARTF VPNSTECGGD 600
KGRVKVITGP NSSGKSIYLK QVGLITFMAL VGSFVPAEEA EIGAVDAIFT RIHSCESISL 660
GLSTFMIDLN QVAKAVNNAT AQSLVLIDEF GKGTNTVDGL ALLAAVLRHW LARGPTCPHI 720
FVATNFLSLV QLQLLPQGPL VQYLTMETCE DGNDLVFFYQ VCEGVAKASH ASHTAAQAGL 780
PDKLVARGKE VSDLIRSGKP IKPVKDLLKK NQMENCQTLV DKFMKLDLED PNLDLNVFMS 840
QEVLPAATSI L 851 
Gene Ontology
 GO:0000795; C:synaptonemal complex; IBA:RefGenome.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008094; F:DNA-dependent ATPase activity; IBA:RefGenome.
 GO:0030983; F:mismatched DNA binding; IBA:RefGenome.
 GO:0051026; P:chiasma assembly; IBA:RefGenome.
 GO:0045143; P:homologous chromosome segregation; IBA:RefGenome.
 GO:0007136; P:meiotic prophase II; TAS:ProtInc.
 GO:0006298; P:mismatch repair; TAS:ProtInc.
 GO:0007131; P:reciprocal meiotic recombination; IBA:RefGenome. 
Interpro
 IPR000432; DNA_mismatch_repair_MutS_C.
 IPR007861; DNA_mismatch_repair_MutS_clamp.
 IPR007696; DNA_mismatch_repair_MutS_core.
 IPR027417; P-loop_NTPase. 
Pfam
 PF05192; MutS_III
 PF05190; MutS_IV
 PF00488; MutS_V 
SMART
 SM00534; MUTSac
 SM00533; MUTSd 
PROSITE
 PS00486; DNA_MISMATCH_REPAIR_2 
PRINTS