UniProt Accession

 TIPRL_HUMAN; O75663; B2R8V3; Q5HYB2; Q8IZ86 

Genbank Protein ID

 AL049670; AB097034; AK313520; AL021397; AL021397; CH471067; BC009506; BX648646 

Genbank Nucleotide ID

 CAB41244.1; BAC77387.1; BAG36300.1; CAA16171.1; CAI22473.1; EAW90821.1; AAH09506.1; CAI46265.1 

Protein Name

 TIP41-like protein 

Protein Synonyms/Alias

 Putative MAPK-activating protein PM10; Type 2A-interacting protein; TIP 

Gene Name

 TIPRL 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
117	WTYTTDYKGTLLGES	ubiquitination	[1]
126	TLLGESLKLKVVPTT	ubiquitination	[1]
128	LGESLKLKVVPTTDH	ubiquitination	[1]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. 

Sequence Annotation

 REGION 173 272 Interaction with PPP2CA.
 MOD_RES 106 106 N6-acetyllysine.  

Keyword

 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 272 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0000077; P:DNA damage checkpoint; IMP:UniProtKB.
 GO:0034048; P:negative regulation of protein phosphatase type 2A activity; IDA:UniProtKB. 

Interpro

 IPR007303; TIP41-like. 

Pfam

 PF04176; TIP41 

SMART

  

PROSITE

  

PRINTS