UniProt Accession

 I7HIK9_MOUSE; I7HIK9 

Genbank Protein ID

 AL731687 

Genbank Nucleotide ID

 CAI52015.1 

Protein Name

 Cellular tumor antigen p53 

Protein Synonyms/Alias

  

Gene Name

 Trp53 

Gene Synonyms/Alias

 RP23-56I20.1-002 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
126	TYSPPLNKLFCQLAK	acetylation	[1]
299	ELPPGSAKRALPTCT	acetylation	[1, 2]
314	SASPPQKKKPLDGEY	acetylation	[1]
315	ASPPQKKKPLDGEYF	acetylation	[1, 2]
325	DGEYFTLKIRGRKRF	acetylation	[2]
372	RAFQALIKEESPNC*	acetylation	[1]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity). 

Sequence Annotation

  

Keyword

 Activator; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 378 AA 

Protein Sequence

Gene Ontology

 GO:0000785; C:chromatin; IBA:RefGenome.
 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IBA:RefGenome.
 GO:0005657; C:replication fork; IDA:MGI.
 GO:0005667; C:transcription factor complex; IBA:RefGenome.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003684; F:damaged DNA binding; IBA:RefGenome.
 GO:0003690; F:double-stranded DNA binding; IBA:RefGenome.
 GO:0035033; F:histone deacetylase regulator activity; IDA:MGI.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0002039; F:p53 binding; IBA:RefGenome.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IBA:RefGenome.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
 GO:0002326; P:B cell lineage commitment; IMP:MGI.
 GO:0007569; P:cell aging; IGI:MGI.
 GO:0071479; P:cellular response to ionizing radiation; IGI:MGI.
 GO:0034644; P:cellular response to UV; IGI:MGI.
 GO:0007417; P:central nervous system development; IGI:MGI.
 GO:0051276; P:chromosome organization; IGI:MGI.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IGI:MGI.
 GO:0006978; P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator; IBA:RefGenome.
 GO:0006302; P:double-strand break repair; IMP:MGI.
 GO:0048568; P:embryonic organ development; IGI:MGI.
 GO:0007369; P:gastrulation; IGI:MGI.
 GO:0001701; P:in utero embryonic development; IGI:MGI.
 GO:0006917; P:induction of apoptosis; IDA:MGI.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IMP:MGI.
 GO:0071850; P:mitotic cell cycle arrest; IDA:MGI.
 GO:0035264; P:multicellular organism growth; IGI:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0008156; P:negative regulation of DNA replication; IDA:MGI.
 GO:0048147; P:negative regulation of fibroblast proliferation; IMP:MGI.
 GO:1901525; P:negative regulation of macromitophagy; IMP:MGI.
 GO:0007406; P:negative regulation of neuroblast proliferation; IGI:MGI.
 GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IMP:MGI.
 GO:0051402; P:neuron apoptotic process; IMP:MGI.
 GO:0010666; P:positive regulation of cardiac muscle cell apoptotic process; IMP:MGI.
 GO:0031065; P:positive regulation of histone deacetylation; IDA:MGI.
 GO:0043525; P:positive regulation of neuron apoptotic process; IDA:MGI.
 GO:0000060; P:protein import into nucleus, translocation; IDA:MGI.
 GO:0051262; P:protein tetramerization; IEA:InterPro.
 GO:1902108; P:regulation of mitochondrial membrane permeability involved in apoptotic process; IGI:MGI.
 GO:0034103; P:regulation of tissue remodeling; IMP:MGI.
 GO:0001836; P:release of cytochrome c from mitochondria; IDA:MGI.
 GO:0042493; P:response to drug; IDA:MGI.
 GO:0010332; P:response to gamma radiation; IDA:MGI.
 GO:0002931; P:response to ischemia; IMP:MGI.
 GO:0006979; P:response to oxidative stress; IMP:MGI.
 GO:0009651; P:response to salt stress; IGI:MGI.
 GO:0010165; P:response to X-ray; IDA:MGI.
 GO:0009303; P:rRNA transcription; IGI:MGI.
 GO:0001756; P:somitogenesis; IGI:MGI.
 GO:0033077; P:T cell differentiation in thymus; IGI:MGI.
 GO:0002360; P:T cell lineage commitment; IMP:MGI.
 GO:0002309; P:T cell proliferation involved in immune response; IGI:MGI.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IGI:MGI. 

Interpro

 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR011615; p53_DNA-bd.
 IPR010991; p53_tetrameristn.
 IPR013872; p53_transactivation_domain.
 IPR002117; p53_tumour_suppressor. 

Pfam

 PF00870; P53
 PF08563; P53_TAD
 PF07710; P53_tetramer 

SMART

  

PROSITE

 PS00348; P53 

PRINTS

 PR00386; P53SUPPRESSR.