CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-015639
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 La-related protein 4 
Protein Synonyms/Alias
 La ribonucleoprotein domain family member 4 
Gene Name
 LARP4 
Gene Synonyms/Alias
 PP13296 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
171ANMEEIKKLTTDPDLubiquitination[1]
194PMVQVDEKGEKVRPSubiquitination[1]
222TTPIEEVKGLFKSENubiquitination[1]
226EEVKGLFKSENCPKVubiquitination[1]
271EVKTFQGKPIMARIKubiquitination[1]
278KPIMARIKAINTFFAubiquitination[1]
286AINTFFAKNGYRLMDubiquitination[1, 2]
378NMGRPFQKNRVKPQFubiquitination[1, 2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [3] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
 Plays a role in the regulation of cell morphology and cytoskeletal organization. 
Sequence Annotation
 DOMAIN 113 202 HTH La-type RNA-binding.
 DOMAIN 203 281 RRM.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 583 583 Phosphoserine.
 MOD_RES 647 647 Phosphoserine.
 MOD_RES 649 649 Phosphothreonine.
 MOD_RES 722 722 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 724 AA 
Protein Sequence
MLLFVEQVAS KGTGLNPNAK VWQEIAPGNT DATPVTHGTE SSWHEIAATS GAHPEVSVFN 60
TGNAELSEDI CKEYEVMYSS SCETTRNTTG IEESTDGMIL GPEDLSYQIY DVSGESNSAV 120
STEDLKECLK KQLEFCFSRE NLSKDLYLIS QMDSDQFIPI WTVANMEEIK KLTTDPDLIL 180
EVLRSSPMVQ VDEKGEKVRP SHKRCIVILR EIPETTPIEE VKGLFKSENC PKVISCEFAH 240
NSNWYITFQS DTDAQQAFKY LREEVKTFQG KPIMARIKAI NTFFAKNGYR LMDSSIYSHP 300
IQTQAQYASP VFMQPVYNPH QQYSVYSIVP QSWSPNPTPY FETPLAPFPN GSFVNGFNSP 360
GSYKTNAAAM NMGRPFQKNR VKPQFRSSGG SEHSTEGSVS LGDGQLNRYS SRNFPAERHN 420
PTVTGHQEQT YLQKETSTLQ VEQNGDYGRG RRTLFRGRRR REDDRISRPH PSTAESKAPT 480
PKFDLLASNF PPLPGSSSRM PGELVLENRM SDVVKGVYKE KDNEELTISC PVPADEQTEC 540
TSAQQLNMST SSPCAAELTA LSTTQQEKDL IEDSSVQKDG LNQTTIPVSP PSTTKPSRAS 600
TASPCNNNIN AATAVALQEP RKLSYAEVCQ KPPKEPSSVL VQPLRELRSN VVSPTKNEDN 660
GAPENSVEKP HEKPEARASK DYSGFRGNII PRGAAGKIRE QRRQFSHRAI PQGVTRRNGK 720
EQYVPPRSPK 730 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0007010; P:cytoskeleton organization; IMP:UniProtKB.
 GO:0022604; P:regulation of cell morphogenesis; IMP:UniProtKB. 
Interpro
 IPR006630; Lupus_La_RNA-bd.
 IPR000504; RRM_dom.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF05383; La 
SMART
 SM00715; LA
 SM00360; RRM 
PROSITE
 PS50961; HTH_LA
 PS50102; RRM 
PRINTS