UniProt Accession

 RAB2A_MOUSE; P53994; Q3UK45 

Genbank Protein ID

 X95403; AK079071; AK135421; AK146179; AK150030; AK159607; AK160333; AK163320 

Genbank Nucleotide ID

 CAA64684.1; BAC37524.1; BAE22525.1; BAE26957.1; BAE29254.1; BAE35226.1; BAE35742.1; BAE37298.1 

Protein Name

 Ras-related protein Rab-2A 

Protein Synonyms/Alias

  

Gene Name

 Rab2a 

Gene Synonyms/Alias

 Rab2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
29	LLLQFTDKRFQPVHD	ubiquitination	[1]
53	RMITIDGKQIKLQIW	acetylation	[2]
56	TIDGKQIKLQIWDTA	ubiquitination	[1]
120	VIMLIGNKSDLESRR	ubiquitination	[1]
130	LESRREVKKEEGEAF	ubiquitination	[1]
165	EAFINTAKEIYEKIQ	ubiquitination	[1]
170	TAKEIYEKIQEGVFD	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Required for protein transport from the endoplasmic reticulum to the Golgi complex (By similarity). 

Sequence Annotation

 NP_BIND 13 21 GTP (By similarity).
 NP_BIND 61 65 GTP (By similarity).
 NP_BIND 119 122 GTP (By similarity).
 NP_BIND 149 151 GTP (By similarity).
 REGION 2 19 Required for interaction with PRKCI (By
 MOTIF 35 43 Effector region (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).
 LIPID 211 211 S-geranylgeranyl cysteine (By
 LIPID 212 212 S-geranylgeranyl cysteine (By  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0033116; C:endoplasmic reticulum-Golgi intermediate compartment membrane; IEA:UniProtKB-SubCell.
 GO:0005794; C:Golgi apparatus; IDA:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0006886; P:intracellular protein transport; TAS:MGI.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
 GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.