CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030689
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Glucose-6-phosphate isomerase 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
12TRDPQFQKLQQWYREubiquitination[1]
128EVNKVLDKMKSFCQGubiquitination[1]
206EWFLQAAKDPSAVAKubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
 Gluconeogenesis; Glycolysis; Isomerase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 530 AA 
Protein Sequence
MAALTRDPQF QKLQQWYREH RSELNLRRLF DANKDRFNHF SLTLNTNHGH ILVDYSKNLV 60
TEDVMRMLVD LAKSRGVEAA RERMFNGEKI NYTEGRAVLH VALRNRSNTP ILVDGKDVMP 120
EVNKVLDKMK SFCQGPLMVT EALKPYSSGG PRVWYVSNID GTHIAKTLAQ LNPESSLFII 180
ASKTFTTQET ITNAETAKEW FLQAAKDPSA VAKHFVALST NTTKVKEFGI DPQNMFEFWD 240
WVGGRYSLWS AIGLSIALHV GFDNFEQLLS GAHWMDQHFR TTPLEKNAPV LLALLGIWYI 300
NCFGCETHAM LPYDQYLHRF AAYFQQGDME SNGKYITKSG TRVDHQTGPI VWGEPGTNGQ 360
HAFYQLIHQG TKMIPCDFLI PVQTQHPIRK GLHHKILLAN FLAQTEALMR GKSTEEARKE 420
LQAAGKSPED LERLLPHKVF EGNRPTNSIV FTKLTPFMLG ALVAMYEHKI FVQGIIWDIN 480
SFDQWGVELG KQLAKKIEPE LDGSAQVTSH DASTNGLINF IKQQREARVQ 530 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0043005; C:neuron projection; IEA:Compara.
 GO:0004347; F:glucose-6-phosphate isomerase activity; IEA:EC.
 GO:0016866; F:intramolecular transferase activity; IEA:Compara.
 GO:0048029; F:monosaccharide binding; IEA:Compara.
 GO:0046185; P:aldehyde catabolic process; IEA:Compara.
 GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
 GO:0051156; P:glucose 6-phosphate metabolic process; IEA:Compara.
 GO:0006096; P:glycolysis; IEA:UniProtKB-UniPathway.
 GO:0007611; P:learning or memory; IEA:Compara.
 GO:0019242; P:methylglyoxal biosynthetic process; IEA:Compara.
 GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IEA:Compara.
 GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Compara. 
Interpro
 IPR001672; G6P_Isomerase.
 IPR023096; G6P_Isomerase_C.
 IPR018189; Phosphoglucose_isomerase_CS. 
Pfam
 PF00342; PGI 
SMART
  
PROSITE
 PS00765; P_GLUCOSE_ISOMERASE_1
 PS00174; P_GLUCOSE_ISOMERASE_2
 PS51463; P_GLUCOSE_ISOMERASE_3 
PRINTS
 PR00662; G6PISOMERASE.