CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018966
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 F-box/WD repeat-containing protein 7 
Protein Synonyms/Alias
 Archipelago homolog; hAgo; F-box and WD-40 domain-containing protein 7; F-box protein FBX30; SEL-10; hCdc4 
Gene Name
 FBXW7 
Gene Synonyms/Alias
 FBW7; FBX30; SEL10 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
412VWSAVTGKCLRTLVGubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin-E, MYC, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. 
Sequence Annotation
 DOMAIN 278 324 F-box.
 REPEAT 378 418 WD 1.
 REPEAT 420 456 WD 2.
 REPEAT 459 498 WD 3.
 REPEAT 500 536 WD 4.
 REPEAT 539 578 WD 5.
 REPEAT 580 618 WD 6.
 REPEAT 622 659 WD 7.
 MOD_RES 227 227 Phosphoserine; by SGK1.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Cytoplasm; Host-virus interaction; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 707 AA 
Protein Sequence
MNQELLSVGS KRRRTGGSLR GNPSSSQVDE EQMNRVVEEE QQQQLRQQEE EHTARNGEVV 60
GVEPRPGGQN DSQQGQLEEN NNRFISVDED SSGNQEEQEE DEEHAGEQDE EDEEEEEMDQ 120
ESDDFDQSDD SSREDEHTHT NSVTNSSSIV DLPVHQLSSP FYTKTTKMKR KLDHGSEVRS 180
FSLGKKPCKV SEYTSTTGLV PCSATPTTFG DLRAANGQGQ QRRRITSVQP PTGLQEWLKM 240
FQSWSGPEKL LALDELIDSC EPTQVKHMMQ VIEPQFQRDF ISLLPKELAL YVLSFLEPKD 300
LLQAAQTCRY WRILAEDNLL WREKCKEEGI DEPLHIKRRK VIKPGFIHSP WKSAYIRQHR 360
IDTNWRRGEL KSPKVLKGHD DHVITCLQFC GNRIVSGSDD NTLKVWSAVT GKCLRTLVGH 420
TGGVWSSQMR DNIIISGSTD RTLKVWNAET GECIHTLYGH TSTVRCMHLH EKRVVSGSRD 480
ATLRVWDIET GQCLHVLMGH VAAVRCVQYD GRRVVSGAYD FMVKVWDPET ETCLHTLQGH 540
TNRVYSLQFD GIHVVSGSLD TSIRVWDVET GNCIHTLTGH QSLTSGMELK DNILVSGNAD 600
STVKIWDIKT GQCLQTLQGP NKHQSAVTCL QFNKNFVITS SDDGTVKLWD LKTGEFIRNL 660
VTLESGGSGG VVWRIRASNT KLVCAVGSRN GTEETKLLVL DFDVDMK 707 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005794; C:Golgi apparatus; IEA:Compara.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0005654; C:nucleoplasm; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0019005; C:SCF ubiquitin ligase complex; IDA:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:Compara.
 GO:0034644; P:cellular response to UV; IDA:UniProtKB.
 GO:0055088; P:lipid homeostasis; ISS:BHF-UCL.
 GO:0030324; P:lung development; IEA:Compara.
 GO:0032876; P:negative regulation of DNA endoreduplication; IMP:BHF-UCL.
 GO:2000346; P:negative regulation of hepatocyte proliferation; ISS:BHF-UCL.
 GO:0045746; P:negative regulation of Notch signaling pathway; ISS:BHF-UCL.
 GO:2000639; P:negative regulation of SREBP signaling pathway; ISS:BHF-UCL.
 GO:0010868; P:negative regulation of triglyceride biosynthetic process; ISS:BHF-UCL.
 GO:0007219; P:Notch signaling pathway; TAS:Reactome.
 GO:0045741; P:positive regulation of epidermal growth factor-activated receptor activity; IDA:BHF-UCL.
 GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IMP:BHF-UCL.
 GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process; IDA:BHF-UCL.
 GO:0050821; P:protein stabilization; IDA:BHF-UCL.
 GO:0016567; P:protein ubiquitination; IDA:UniProtKB.
 GO:0010883; P:regulation of lipid storage; ISS:BHF-UCL.
 GO:0032880; P:regulation of protein localization; ISS:BHF-UCL.
 GO:0006974; P:response to DNA damage stimulus; IDA:UniProtKB.
 GO:0031146; P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; IDA:UniProtKB.
 GO:0007062; P:sister chromatid cohesion; IMP:BHF-UCL.
 GO:0001944; P:vasculature development; TAS:BHF-UCL.
 GO:0001570; P:vasculogenesis; IEA:Compara.
 GO:0019048; P:virus-host interaction; IEA:UniProtKB-KW. 
Interpro
 IPR001810; F-box_dom_cyclin-like.
 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00256; FBOX
 SM00320; WD40 
PROSITE
 PS50181; FBOX
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS
 PR00320; GPROTEINBRPT.