CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030957
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 cDNA FLJ55705, highly similar to Threonyl-tRNA synthetase, cytoplasmic (EC 6.1.1.3) 
Protein Synonyms/Alias
  
Gene Name
  
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
110ETLLAMFKYNKFKCRubiquitination[1]
122KCRILNEKVNTPTTTubiquitination[1]
383NLSTRPEKFLGDIEVubiquitination[1]
428PKIDIQIKDAIGRYHubiquitination[1]
515TCDEYAQKVRQQFHDubiquitination[1]
591IERLQQLKEFRSKQAubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; Ligase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 602 AA 
Protein Sequence
MIPFWQKRQK KIASQLKSLC PMVNRLMRNL GKLHHIKLPV ELAMERVYGG CLCYGPPIEN 60
GFYYDMYLEE GGVSSNDFSS LEALCKKIIK EKQAFERLEV KKETLLAMFK YNKFKCRILN 120
EKVNTPTTTV YRCGPLIDLC RGPHVRHTGK IKALKIHKNS STYWEGKADM ETLQRIYGIS 180
FPDPKMLKEW EKFQEEAKNR DHRKIGRDQE LYFFHELSPG SCFFLPKGAY IYNALIEFIR 240
SEYRKRGFQE VVTPNIFNSR LWMTSGHWQH YSENMFSFEV EKELFALKPM NCPGHCLMFD 300
HRPRSWRELP LRLADFGVLH RNELSGALTG LTRVRRFQQD DAHIFCAMEQ IEDEIKGCLD 360
FLRTVYSVFG FSFKLNLSTR PEKFLGDIEV WDQAEKQLEN SLNEFGEKWE LNSGDGAFYG 420
PKIDIQIKDA IGRYHQCATI QLDFQLPIRF NLTYVSHDGD DKKRPVIVHR AILGSVERMI 480
AILTENYGGK WPFWLSPRQV MVVPVGPTCD EYAQKVRQQF HDAKFMADID LDPGCTLNKK 540
IRNAQLAQYN FILVVGEKEK ISGTVNIRTR DNKVHGERTI SETIERLQQL KEFRSKQAEE 600
EF 602 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004829; F:threonine-tRNA ligase activity; IEA:InterPro.
 GO:0006435; P:threonyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR002320; Thr-tRNA-ligase_IIa.
 IPR018163; Thr/Ala-tRNA-synth_IIc_edit.
 IPR012947; tRNA_SAD. 
Pfam
 PF03129; HGTP_anticodon
 PF00587; tRNA-synt_2b
 PF07973; tRNA_SAD 
SMART
 SM00863; tRNA_SAD 
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01047; TRNASYNTHTHR.