CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014024
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger and BTB domain-containing protein 37 
Protein Synonyms/Alias
  
Gene Name
 ZBTB37 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
385CAKSFNQKGSLDRHMubiquitination[1]
413CGKKYTRKDQLEYHIubiquitination[2]
Reference
 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 May be involved in transcriptional regulation. 
Sequence Annotation
 DOMAIN 32 96 BTB.
 ZN_FING 373 395 C2H2-type 1.
 ZN_FING 401 423 C2H2-type 2.
 ZN_FING 429 452 C2H2-type 3.  
Keyword
 Alternative splicing; Complete proteome; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 503 AA 
Protein Sequence
MEKGGNIQLE IPDFSNSVLS HLNQLRMQGR LCDIVVNVQG QAFRAHKVVL AASSPYFRDH 60
MSLNEMSTVS ISVIKNPTVF EQLLSFCYTG RICLQLADII SYLTAASFLQ MQHIIDKCTQ 120
ILEGIHFKIN VAEVEAELSQ TRTKHQERPP ESHRVTPNLN RSLSPRHNTP KGNRRGQVSA 180
VLDIRELSPP EESTSPQIIE PSSDVESREP ILRINRAGQW YVETGVADRG GRSDDEVRVL 240
GAVHIKTENL EEWLGPENQP SGEDGSSAEE VTAMVIDTTG HGSVGQENYT LGSSGAKVAR 300
PTSSEVDRFS PSGSVVPLTE RHRARSESPG RMDEPKQPSS QVEESAMMGV SGYVEYLREQ 360
EVSERWFRYN PRLTCIYCAK SFNQKGSLDR HMRLHMGITP FVCRMCGKKY TRKDQLEYHI 420
RKHTGNKPFH CHVCGKSFPF QAILNQHFRK NHPGCIPLEG PHSISPETTV TSRGQAEEES 480
PSQEETVAPG EAVQGSVSTT GPD 503 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00651; BTB 
SMART
 SM00225; BTB
 SM00355; ZnF_C2H2 
PROSITE
 PS50097; BTB
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS