CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040687
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 SPRY domain-containing protein 3 
Protein Synonyms/Alias
  
Gene Name
 SPRYD3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
51YRFVLMNKMDDLNLHubiquitination[1, 2]
202TAQIFFTKNGKRVGSubiquitination[3]
277LEYLGKGKSIVDVGLubiquitination[2, 4]
341AYHADDGKIFHGSGVubiquitination[2]
358PFGPRCYKGDIMGCGubiquitination[2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 479 AA 
Protein Sequence
MRRTRRPRVL LCQPGWNVVA QSELTAALTC QTQAIFSLLS SWDYRFVLMN KMDDLNLHYR 60
FLNWRRRIRE IREVRAFRYQ ERFKHILVDG DTLSYHGNSG EVGCYVASRP LTKDSNYFEV 120
SIVDSGVRGT IAVGLVPQYY SLDHQPGWLP DSVAYHADDG KLYNGRAKGR QFGSKCNSGD 180
RIGCGIEPVS FDVQTAQIFF TKNGKRVGST IMPMSPDGLF PAVGMHSLGE EVRLHLNAEL 240
GREDDSVMMV DSYEDEWGRL HDVRVCGTLL EYLGKGKSIV DVGLAQARHP LSTRSHYFEV 300
EIVDPGEKCY IALGLARKDY PKNRHPGWSR GSVAYHADDG KIFHGSGVGD PFGPRCYKGD 360
IMGCGIMFPR DYILDSEGDS DDSCDTVILS PTARAVRNVR NVMYLHQEGE EEEEEEEEEE 420
DGEEIEPEHE GRKVVVFFTR NGKIIGKKDA VVPSGGFFPT IGMLSCGEKV KVDLHPLSG 479 
Gene Ontology
  
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF00622; SPRY 
SMART
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY 
PRINTS