UniProt Accession

 GROU_DROME; P16371; A4V3F6; Q0KI08; Q7KRZ4; Q9V3F7 

Genbank Protein ID

 M20571; AE014297; AE014297; AE014297; AE014297; AF145695 

Genbank Nucleotide ID

 AAA28512.1; AAF56557.1; AAN14068.1; AAN14069.1; AAS65218.1; AAD38670.1 

Protein Name

 Protein groucho 

Protein Synonyms/Alias

 Enhancer of split m9/10 protein; E(spl)m9/10 

Gene Name

 gro 

Gene Synonyms/Alias

 E(spl)m9/m10; CG8384 

Created Date

 July 27, 2013 

Organism

 Drosophila melanogaster (Fruit fly) 

NCBI Taxa ID

 7227 

Lysine Modification

Position	Peptide	Type	References
167	GPQGLLNKPPEHHRP	sumoylation	[1]
177	EHHRPDIKPTGLEGP	sumoylation	[1]
272	LNGERLEKPSSSGIK	sumoylation	[1]
279	KPSSSGIKQERPPSR	sumoylation	[1]

Reference

 [1] Covalent conjugation of Groucho with SUMO-1 modulates its corepressor activity.
 Ahn JW, Lee YA, Ahn JH, Choi CY.
 Biochem Biophys Res Commun. 2009 Jan 30;379(1):160-5. [PMID: 19101520] 

Functional Description

 Transcriptional corepressor that regulates transcription when recruited to specific target DNA by hairy-related bHLH proteins. Maternally required for neurogenesis; in the segregation of the neuroectoderm. Directly or indirectly interacts with Notch and Delta. 

Sequence Annotation

 REPEAT 442 480 WD 1.
 REPEAT 488 527 WD 2.
 REPEAT 532 571 WD 3.
 REPEAT 574 613 WD 4.
 REPEAT 615 654 WD 5.
 REPEAT 656 695 WD 6.
 REPEAT 697 730 WD 7.
 REGION 206 267 CCN domain.
 REGION 262 425 Binding to basic helix-loop-helix domain.
 MOTIF 227 230 Nuclear localization signal (Potential).
 MOD_RES 205 205 Phosphoserine.
 MOD_RES 207 207 Phosphoserine.
 MOD_RES 218 218 Phosphoserine.
 MOD_RES 242 242 Phosphoserine; by CK2 (Potential).
 MOD_RES 258 258 Phosphoserine; by CDC2 (Potential).
 MOD_RES 267 267 Phosphoserine.
 MOD_RES 326 326 Phosphothreonine.
 MOD_RES 328 328 Phosphothreonine.  

Keyword

 Alternative splicing; Complete proteome; Developmental protein; Differentiation; Neurogenesis; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation; WD repeat; Wnt signaling pathway. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 730 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; TAS:FlyBase.
 GO:0043234; C:protein complex; IPI:FlyBase.
 GO:0070491; F:repressing transcription factor binding; IGI:FlyBase.
 GO:0001106; F:RNA polymerase II transcription corepressor activity; IGI:FlyBase.
 GO:0007015; P:actin filament organization; IMP:FlyBase.
 GO:0048813; P:dendrite morphogenesis; IMP:FlyBase.
 GO:0046331; P:lateral inhibition; IMP:FlyBase.
 GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway; IDA:UniProtKB.
 GO:0045879; P:negative regulation of smoothened signaling pathway; IMP:FlyBase.
 GO:0007541; P:sex determination, primary response to X:A ratio; TAS:FlyBase.
 GO:0016055; P:Wnt receptor signaling pathway; IEA:UniProtKB-KW. 

Interpro

 IPR005617; Groucho/TLE_N.
 IPR009146; Groucho_enhance.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF03920; TLE_N
 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR01850; GROUCHOFAMLY.