CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019008
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cirhin 
Protein Synonyms/Alias
  
Gene Name
 CIRH1A 
Gene Synonyms/Alias
 KIAA1988 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
502SLPLPNDKTLLYNPFubiquitination[1]
565AQLPPPIKKKKFGT*ubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 May be a transcriptional regulator. Acts as a positive regulator of HIVEP1 which specifically binds to the DNA sequence 5'-GGGACTTTCC-3' found in enhancer elements of numerous viral promoters such as those of HIV-1, SV40, or CMV. 
Sequence Annotation
 REPEAT 14 53 WD 1.
 REPEAT 57 96 WD 2.
 REPEAT 99 138 WD 3.
 REPEAT 143 181 WD 4.
 REPEAT 193 231 WD 5.
 REPEAT 234 273 WD 6.
 REPEAT 285 322 WD 7.
 REPEAT 324 359 WD 8.
 REPEAT 435 475 WD 9.
 REPEAT 482 521 WD 10.
 REPEAT 524 563 WD 11.  
Keyword
 Alternative splicing; Complete proteome; Disease mutation; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 686 AA 
Protein Sequence
MGEFKVHRVR FFNYVPSGIR CVAYNNQSNR LAVSRTDGTV EIYNLSANYF QEKFFPGHES 60
RATEALCWAE GQRLFSAGLN GEIMEYDLQA LNIKYAMDAF GGPIWSMAAS PSGSQLLVGC 120
EDGSVKLFQI TPDKIQFERN FDRQKSRILS LSWHPSGTHI AAGSIDYISV FDVKSGSAVH 180
KMIVDRQYMG VSKRKCIVWG VAFLSDGTII SVDSAGKVQF WDSATGTLVK SHLIANADVQ 240
SIAVADQEDS FVVGTAEGTV FHFQLVPVTS NSSEKQWVRT KPFQHHTHDV RTVAHSPTAL 300
ISGGTDTHLV FRPLMEKVEV KNYDAALRKI TFPHRCLISC SKKRQLLLFQ FAHHLELWRL 360
GSTVATGTVE AMCLLAVSPD GNWLAASGTS AGVHVYNVKQ LKLHCTVPAY NFPVTAMAIA 420
PNTNNLVIAH SDQQVFEYSI PDKQYTDWSR TVQKQGFHHL WLQRDTPITH ISFHPKRPMH 480
ILLHDAYMFC IIDKSLPLPN DKTLLYNPFP PTNESDVIRR RTAHAFKISK IYKPLLFMDL 540
LDERTLVAVE RPLDDIIAQL PPPIKKKKFG T 571 
Gene Ontology
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0006355; P:regulation of transcription, DNA-dependent; IDA:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR011047; Quinonprotein_ADH-like_supfam.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF00400; WD40 
SMART
 SM00320; WD40 
PROSITE
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS