| Tag | Content |
|---|
| CPLM ID | CPLM-010883 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Aspartate aminotransferase, mitochondrial |
Protein Synonyms/Alias | Transaminase A |
Gene Name | AAT1 |
Gene Synonyms/Alias | YKL106W; YKL461 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 30 | VPRAPPDKVLGLSEH | acetylation | [1] | | 39 | LGLSEHFKKVKNVNK | acetylation | [1] | | 310 | PATANNGKFNPLQQK | acetylation | [1] | | 355 | NVVLSDFKLKQQWFK | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol (By similarity). |
Sequence Annotation | BINDING 52 52 Aspartate; via amide nitrogen (By
BINDING 155 155 Aspartate (By similarity).
BINDING 216 216 Aspartate (By similarity).
BINDING 423 423 Aspartate (By similarity).
MOD_RES 286 286 N6-(pyridoxal phosphate)lysine (By |
Keyword | Aminotransferase; Complete proteome; Mitochondrion; Pyridoxal phosphate; Reference proteome; Transferase; Transit peptide. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 451 AA |
Protein Sequence | MLRTRLTNCS LWRPYYTSSL SRVPRAPPDK VLGLSEHFKK VKNVNKIDLT VGIYKDGWGK 60
VTTFPSVAKA QKLIESHLEL NKNLSYLPIT GSKEFQENVM KFLFKESCPQ FGPFYLAHDR 120
ISFVQTLSGT GALAVAAKFL ALFISRDIWI PDPSWANHKN IFQNNGFENI YRYSYYKDGQ 180
IDIDGWIEQL KTFAYNNQQE NNKNPPCIIL HACCHNPTGL DPTKEQWEKI IDTIYELKMV 240
PIVDMAYQGL ESGNLLKDAY LLRLCLNVNK YPNWSNGIFL CQSFAKNMGL YGERVGSLSV 300
ITPATANNGK FNPLQQKNSL QQNIDSQLKK IVRGMYSSPP GYGSRVVNVV LSDFKLKQQW 360
FKDVDFMVQR LHHVRQEMFD RLGWPDLVNF AQQHGMFYYT RFSPKQVEIL RNNYFVYLTG 420
DGRLSLSGVN DSNVDYLCES LEAVSKMDKL A 451 |
Gene Ontology | GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell. GO:0005739; C:mitochondrion; ISS:UniProtKB. GO:0004069; F:L-aspartate:2-oxoglutarate aminotransferase activity; ISS:UniProtKB. GO:0080130; F:L-phenylalanine:2-oxoglutarate aminotransferase activity; IEA:EC. GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro. GO:0006103; P:2-oxoglutarate metabolic process; ISS:UniProtKB. GO:0019266; P:asparagine biosynthetic process from oxaloacetate; IC:SGD. GO:0006532; P:aspartate biosynthetic process; IMP:SGD. GO:0001300; P:chronological cell aging; IMP:SGD. GO:0006536; P:glutamate metabolic process; ISS:UniProtKB. GO:0001302; P:replicative cell aging; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |