| Tag | Content |
|---|
| CPLM ID | CPLM-021884 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Scm-like with four MBT domains protein 1 |
Protein Synonyms/Alias | |
Gene Name | Sfmbt1 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 792 | HLDSNPLKWSVADVV | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Histone-binding protein, which is part of various corepressor complexes. Mediates the recruitment of corepressor complexes to target genes, followed by chromatin compaction and repression of transcription. Plays a role during myogenesis: required for the maintenance of undifferentiated states of myogenic progenitor cells via interaction with MYOD1. Interaction with MYOD1 leads to the recruitment of associated corepressors and silencing of MYOD1 target genes. Part of the SLC complex in germ cells, where it may play a role during spermatogenesis. |
Sequence Annotation | REPEAT 20 120 MBT 1.
REPEAT 128 232 MBT 2.
REPEAT 242 346 MBT 3.
REPEAT 354 451 MBT 4.
DOMAIN 793 861 SAM.
MOD_RES 772 772 Phosphoserine (By similarity). |
Keyword | Chromatin regulator; Complete proteome; Differentiation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Spermatogenesis; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 863 AA |
Protein Sequence | MSGEQQLDAD LGSGVEVEEF SWEDYLEETG STTVPYASFK HVDIRLQNGF APGMKLEVAL 60
KNDPETYWVA TIITACEQLL LLRYEGYGED RKADFWCDIR KAGLYPIGWC QQNKKTLEAP 120
EGIRDKVSDW NAFLQQTLIG ACGPPVSLLE GLRNGRNPLD LIAPGSKLEC QDFRDSLSTW 180
LVTVVENIGG RLKLRYEGLE SRDGFEHWLY YLDPFLHHIG WAAQQGCDLQ PPLAIKHLKS 240
EADWQEILAK VKEEEPLPSY LFKDKQVIGT HEFSINMKLE AVDPWSPFGI SPATIAKVFD 300
DKYFLVEMDD LRPEDHTRRS FVCHANSPGI FPVQWSLKNG LHINPPPGFR SQDFDWADYL 360
KQCGAEAAPQ KCFPQSISEH QFKENMKLEA VNPLFPEEVC IATVTAVRGS YLWLQLEGSK 420
KPVPEFIVSA ESMNIFPLGW CETNGHPLST PRRARGHKLR KIAVVQPEKQ ILSSRTVHEG 480
LKNQLNSTHS VMINGKYCCP KIYFNHRCFS GPYLNKGRIA ELPQCVGPGN CVLVLREVLT 540
LLINAAYKPS RVLRELQLDK DSVWHGCGEV LKAKYKGKSY RATVEIVRTA DRVTEFCRQT 600
CIKLECCPNL FGPRMVLDTC SENCSVLTKT KYTHYYGKKK NKRIGRPPGG HSNLSCALKK 660
SSKRRKRRKN IFVHKKKRSS ASVDNTPVGS PQGSGGEDEE DADDGDEDSL TEGSTSEQQE 720
ELQEESEVSE KKSSSSSPTQ SETPTPLPPD TQTNKRDAQT SSVSDDENKP PSPKEIRIEV 780
DERLHLDSNP LKWSVADVVR FIRSTDCAPL ARIFLDQEID GQALLLLTLP TVQECMDLKL 840
GPAIKLCHHI ERIKFAFYEQ FAN 863 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0016568; P:chromatin modification; IEA:UniProtKB-KW. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |