UniProt Accession

 MAFG_RAT; Q76MX4; Q99N83 

Genbank Protein ID

 AB026487; AB050011; CH473948; CH473948; CH473948; BC078828 

Genbank Nucleotide ID

 BAA85331.1; BAB41097.1; EDM06874.1; EDM06875.1; EDM06876.1; AAH78828.1 

Protein Name

 Transcription factor MafG 

Protein Synonyms/Alias

 V-maf musculoaponeurotic fibrosarcoma oncogene homolog G 

Gene Name

 Mafg 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
6	**MTTPNKGNKALKV	acetylation	[1]
9	TTPNKGNKALKVSGE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins and recruiting them to specific DNA-binding sites. Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor. Transcription factor, component of erythroid-specific transcription factor NF- E2. Activates globin gene expression when associated with NF-E2 (By similarity). May be involved in signal transduction of extracellular H(+). 

Sequence Annotation

 DOMAIN 78 141 bZIP.
 REGION 80 103 Basic motif (By similarity).
 REGION 106 120 Leucine-zipper (By similarity).
 MOD_RES 80 80 N6-acetyllysine (Probable).
 MOD_RES 87 87 N6-acetyllysine (Probable).
 MOD_RES 98 98 N6-acetyllysine (Probable).
 MOD_RES 103 103 N6-acetyllysine (Probable).
 MOD_RES 151 151 Phosphoserine (By similarity).
 CROSSLNK 41 41 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 189 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0030534; P:adult behavior; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0042127; P:regulation of cell proliferation; IEA:Compara.
 GO:0030641; P:regulation of cellular pH; IDA:RGD.
 GO:0045604; P:regulation of epidermal cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR004827; bZIP.
 IPR004826; bZIP_Maf.
 IPR008917; Euk_TF_DNA-bd.
 IPR024874; Transciption_factor_Maf. 

Pfam

 PF03131; bZIP_Maf 

SMART

 SM00338; BRLZ 

PROSITE

 PS50217; BZIP 

PRINTS