UniProt Accession

 CP3AD_MOUSE; Q64464 

Genbank Protein ID

 X63023; BC046592 

Genbank Nucleotide ID

 CAA44754.1; AAH46592.1 

Protein Name

 Cytochrome P450 3A13 

Protein Synonyms/Alias

 CYPIIIA13 

Gene Name

 Cyp3a13 

Gene Synonyms/Alias

 Cyp3a-13 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
42	KLGIPGPKPLPFLGT	ubiquitination	[1]
66	ECDIQCHKKYGKMWG	acetylation	[2]
66	ECDIQCHKKYGKMWG	ubiquitination	[1]
91	ITDPDIIKTVLVKEC	ubiquitination	[1]
96	IIKTVLVKECYSTFT	ubiquitination	[1]
115	FGPVGILKKAISISE	ubiquitination	[1]
116	GPVGILKKAISISEN	ubiquitination	[1]
143	TFTSGRLKEMFPIIN	ubiquitination	[1]
168	RQGLGEGKPTSMKDI	ubiquitination	[1]
282	MINSQNYKTKESHKA	ubiquitination	[1]
330	IHPDVQKKLQDEIDA	ubiquitination	[1]
378	GRLERVCKTDVEING	ubiquitination	[1]
403	IPTFALHKDPKYWPE	ubiquitination	[1]
406	FALHKDPKYWPEPEE	ubiquitination	[1]
422	RPERFSKKNQDSINP	ubiquitination	[1]
469	NFTVQPCKETEIPLK	ubiquitination	[1]
476	KETEIPLKLSKQGLL	ubiquitination	[1]
479	EIPLKLSKQGLLQPE	ubiquitination	[1]
492	PENPLLLKVVSRDET	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Can activate aflatoxin B1 to a genotoxic product. 

Sequence Annotation

 METAL 442 442 Iron (heme axial ligand) (By similarity).  

Keyword

 Complete proteome; Endoplasmic reticulum; Heme; Iron; Membrane; Metal-binding; Microsome; Monooxygenase; Oxidoreductase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 503 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0070330; F:aromatase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004497; F:monooxygenase activity; ISS:UniProtKB.
 GO:0010628; P:positive regulation of gene expression; IMP:MGI. 

Interpro

 IPR001128; Cyt_P450.
 IPR017972; Cyt_P450_CS.
 IPR008072; Cyt_P450_E_CYP3A.
 IPR002402; Cyt_P450_E_grp-II. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00464; EP450II.
 PR01689; EP450IICYP3A.
 PR00385; P450.