UniProt Accession

 C9JBL1_HUMAN; C9JBL1 

Genbank Protein ID

 AC104446 

Genbank Nucleotide ID

  

Protein Name

 Signal peptidase complex subunit 1 

Protein Synonyms/Alias

  

Gene Name

 SPCS1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
54	IYRRHPLKWLPVQES	ubiquitination	[1, 2, 3]
67	ESSTDDKKPGERKIK	ubiquitination	[4]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 80 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005787; C:signal peptidase complex; IEA:InterPro.
 GO:0008233; F:peptidase activity; IEA:InterPro.
 GO:0043022; F:ribosome binding; IEA:Compara.
 GO:0006465; P:signal peptide processing; IEA:InterPro. 

Interpro

 IPR009542; SPC12. 

Pfam

 PF06645; SPC12 

SMART

  

PROSITE

  

PRINTS